onmel

How long does Itraconazole stay in your body?

The elimination half-life of itraconazole is Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing. — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The label reports the terminal half-life explicitly (not a distribution phase). Itraconazole has an ACTIVE metabolite, hydroxy-itraconazole, whose in-vitro antifungal activity is comparable to the parent and whose trough plasma concentrations are about twice those of itraconazole, so effective antifungal exposure persists beyond the parent's half-life. Populations: in cirrhotic (hepatic impairment) subjects the elimination half-life roughly doubled to about 37 hours (vs ~16 hours in healthy subjects after a single 100 mg capsule). In renal impairment, the mean terminal half-life was similar to healthy subjects (range of means ~42-49 hours vs 48 hours after a single IV dose), though overall AUC exposure fell ~30-40% in moderate-to-severe impairment; dialysis has no effect on itraconazole or hydroxy-itraconazole half-life. The label does not give a separate geriatric half-life. Note also non-linear pharmacokinetics: itraconazole accumulates with multiple dosing (clearance saturates), which is why the half-life lengthens at steady state.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Itraconazole capsules — FDA label (DailyMed), Clinical Pharmacology, Pharmacokinetics and Metabolism.

Frequently asked questions

What does Onmel treat?

Onmel (Itraconazole) may be used to treat aspergillosis, blastomycosis, chronic mucocutaneous candidiasis, oral candidiasis, vulvovaginal candidiasis, coccidioidomycosis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Onmel work?

Onmel is a azole antifungal. Azole antifungals block a fungal enzyme (lanosterol 14-alpha-demethylase) that the fungus needs to make ergosterol, a key building block of its cell membrane. Without enough ergosterol the membrane becomes leaky and unstable, which stops the fungus from growing and can cause it to break apart and die.

How much does Onmel cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.84 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Clotrimazole — about $0.21 on the same basis.

Is there a coupon or discount for Onmel?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Onmel. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Onmel?

Onmel is marketed by Sebela Ireland Ltd. You can see Sebela Ireland Ltd's full profile, rating, and other products on pharmaranks.

Is Onmel a brand-name or generic drug?

Onmel is a brand-name product with the active ingredient Itraconazole.

Is Onmel available over the counter?

No. Onmel is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Onmel come in?

Onmel is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Onmel?

Onmel is classified as azole antifungal, per the FDA's Established Pharmacologic Class.

Is Onmel FDA-registered?

Onmel is on record with the U.S. FDA under application number NDA022484. You can verify this on its official FDA label.