Skip to content
ppharmaranks
Menu

Which pills you can crush or split

Quoted from each drug’s own FDA label, per product — because the answer belongs to the form, not the drug name. An extended-release tablet releases a whole day’s dose at once when it is crushed; the immediate-release version of the same drug often carries no restriction at all.

By the pharmaranks editorial teamReviewed against the FDA drug labels (DailyMed) sourcesUpdated Jul 28, 2026How we research

Drugs whose labels carry an instruction (177)

  • Can you crush Acetaminophen?

    Swallow whole — the label says not to crush or chew it · Acetaminophen

    Adults: take 2 tablets every 8 hours with water swallow whole; do not crush, chew, split or dissolve do not take more than 6 tablets in 24 hours do not use for more than 10 days unless directed by a doctor. label ↗

    50 labels read

  • Can you crush Albendazole?

    The label allows it, in the terms quoted · ALBENZA

    ALBENZA tablets may be crushed or chewed and swallowed with a drink of water. label ↗

    10 labels read

  • Can you crush Alfuzosin?

    Swallow whole — the label says not to crush or chew it · Alfuzosin Hydrochloride

    The tablets should not be chewed or crushed. label ↗

    17 labels read

  • Can you crush Alprazolam?

    Swallow whole — the label says not to crush or chew it · Alprazolam

    Swallow tablets whole; do not divide, crush, or chew. label ↗

    50 labels read

  • Can you crush Amantadine?

    Swallow whole — the label says not to crush or chew it · GOCOVRI

    Do not crush, chew, or divide. label ↗

    The label allows it, in the terms quoted · Amantadine HCL

    The daily dosage may be split into one tablet of 100 mg twice a day. label ↗

    50 labels read

  • Can you crush Ambrisentan?

    Swallow whole — the label says not to crush or chew it · Ambrisentan

    Do not split, crush, or chew tablets. label ↗

    14 labels read

  • Can you crush Apixaban?

    Swallow whole — the label says not to crush or chew it · ELIQUIS

    For patients who are unable to swallow whole tablets, 5 mg and 2. label ↗

    It depends on what you mean — read the sentence · apixaban

    D5W), or apple juice, or mixed with applesauce and promptly administered orally [see Clinical Pharmacology. label ↗

    The label allows it, in the terms quoted · ELIQUIS

    Alternatively, ELIQUIS tablets may be crushed and suspended in 60 mL of water or D5W and promptly delivered through a nasogastric tube [see Clinical Pharmacology. label ↗

    11 labels read

  • Can you crush Asenapine?

    Swallow whole — the label says not to crush or chew it · Asenapine

    Do not cut or tear the tablet pack. label ↗

    7 labels read

  • Can you crush Azacitidine?

    Swallow whole — the label says not to crush or chew it · ONUREG

    Do not cut, crush, or chew the tablets. label ↗

    27 labels read

  • Can you crush Balsalazide Disodium?

    Swallow whole — the label says not to crush or chew it · Balsalazide Disodium

    Do not cut, break, crush or chew. label ↗

    The label allows it, in the terms quoted · Balsalazide Disodium

    The contents may be chewed, if necessary. label ↗

    9 labels read

  • Can you crush Barium?

    Swallow whole — the label says not to crush or chew it · E-Z-Disk

    Do not cut, crush, or chew the tablet. label ↗

    50 labels read

  • Can you crush Benzonatate?

    Swallow whole — the label says not to crush or chew it · Benzonatate

    BENZONATATE should be swallowed whole. label ↗

    50 labels read

  • Can you crush Bosentan?

    Swallow whole — the label says not to crush or chew it · Bosentan

    Decreases in sperm count, Fluid retention Administration Considerations Advise patients that bosentan tablets for oral suspension dispersible tablets should not be split into quarters. label ↗

    8 labels read

  • Can you crush Bosutinib?

    Swallow whole — the label says not to crush or chew it · BOSULIF

    Capsules may be swallowed whole. label ↗

    5 labels read

  • Can you crush Brivaracetam?

    Swallow whole — the label says not to crush or chew it · Briviact

    BRIVIACT tablets should not be chewed or crushed. label ↗

    20 labels read

  • Can you crush Budesonide?

    Swallow whole — the label says not to crush or chew it · Budesonide

    Do not chew or crush the granules. label ↗

    50 labels read

  • Can you crush Buprenorphine?

    Swallow whole — the label says not to crush or chew it · Buprenorphine

    Do not cut, chew, or swallow buprenorphine sublingual tablet. label ↗

    50 labels read

  • Can you crush Bupropion?

    Swallow whole — the label says not to crush or chew it · Bupropion Hydrochloride SR

    Do not chew, divide, or crush tablets; they are designed to slowly release drug in the body. label ↗

    50 labels read

  • Can you crush Caffeine?

    Swallow whole — the label says not to crush or chew it · Uplift Chewable

    Do not swallow whole Warnings For occasional use only. label ↗

    50 labels read

  • Can you crush Capecitabine?

    Swallow whole — the label says not to crush or chew it · Capecitabine

    Do not crush or cut capecitabine tablets. label ↗

    21 labels read

  • Can you crush Carbamazepine?

    Swallow whole — the label says not to crush or chew it · Carbamazepine

    Tegretol-XR tablets must be swallowed whole and never crushed or chewed. label ↗

    50 labels read

  • Can you crush Carglumic Acid?

    Swallow whole — the label says not to crush or chew it · Carbaglu

    Do not swallow whole or crush. label ↗

    4 labels read

  • Can you crush Carvedilol?

    Swallow whole — the label says not to crush or chew it · Carvedilol Phosphate

    Do not crush or chew capsules. label ↗

    50 labels read

  • Can you crush Cefaclor?

    The label allows it, in the terms quoted · Cefaclor

    Treatment Option —For the treatment of otitis media and pharyngitis, the total daily dosage may be divided and administered every 12 hours. label ↗

    4 labels read

  • Can you crush Cefixime?

    The label allows it, in the terms quoted · Cefixime

    This may be given as a 400 mg tablet daily or the 400 mg tablet may be split and given as one half tablet every 12 hours. label ↗

    8 labels read

  • Can you crush Cephalexin?

    The label allows it, in the terms quoted · CEPHALEXIN

    For streptococcal pharyngitis in patients over 1 year of age and for skin and skin structure infections, the total daily dose may be divided and administered every 12 hours. label ↗

    50 labels read

  • Can you crush Ciprofloxacin?

    Swallow whole — the label says not to crush or chew it · Ciprofloxacin

    Not to chew the microcapsules, but to swallow them whole. label ↗

    The label allows it, in the terms quoted · Ciprofloxacin

    Advise patients that ciprofloxacin tablets (250 mg and 500 mg) are scored and can be split into one-half at the scored line to provide a 125 mg or 250 mg strength, respectively. label ↗

    50 labels read

  • Can you crush Cladribine?

    Swallow whole — the label says not to crush or chew it · Mavenclad

    MAVENCLAD tablets are taken orally, with water, and swallowed whole without chewing. label ↗

    8 labels read

  • Can you crush Clarithromycin?

    Swallow whole — the label says not to crush or chew it · Clarithromycin

    Swallow clarithromycin extended-release tablets whole; do not chew, break or crush clarithromycin extended-release tablets. label ↗

    44 labels read

  • Can you crush Clindamycin?

    Swallow whole — the label says not to crush or chew it · Clindamycin Phosphate

    Do not break through (puncture) the clindamycin phosphate foam can. label ↗

    50 labels read

  • Can you crush Clobazam?

    Swallow whole — the label says not to crush or chew it · SYMPAZAN

    Do not chew, spit, or talk while SYMPAZAN dissolves. label ↗

    22 labels read

  • Can you crush Clobetasol?

    Swallow whole — the label says not to crush or chew it · Tovet (emollient formulation)

    Do not break through (puncture) Tovet Foam can. label ↗

    50 labels read

  • Can you crush Clonidine?

    Swallow whole — the label says not to crush or chew it · Clonidine Hydrochloride

    Do not crush, chew or break tablet before swallowing. label ↗

    50 labels read

  • Can you crush Clozapine?

    The label allows it, in the terms quoted · Clozapine

    The tablets can be allowed to disintegrate, or they may be chewed. label ↗

    15 labels read

  • Can you crush Colestipol?

    Swallow whole — the label says not to crush or chew it · Colestipol hydrochloride

    Do not cut, crush or chew the tablets. label ↗

    12 labels read

  • Can you crush Copper?

    Swallow whole — the label says not to crush or chew it · Miudella

    Completely remove the white release thread from the inserter until you see the free end of the thread Do not cut the white release thread. label ↗

    50 labels read

  • Can you crush Cyclophosphamide?

    Swallow whole — the label says not to crush or chew it · Cyclophosphamide

    The tablets should not be chewed or crushed. label ↗

    33 labels read

  • Can you crush Cysteamine?

    Swallow whole — the label says not to crush or chew it · PROCYSBI

    Do not crush or chew oral granules. label ↗

    4 labels read

  • Can you crush Dabigatran Etexilate?

    Swallow whole — the label says not to crush or chew it · Pradaxa

    PRADAXA Capsules should be swallowed whole. label ↗

    21 labels read

  • Can you crush Dalfampridine?

    Swallow whole — the label says not to crush or chew it · Dalfampridine

    Administer tablets whole; do not divide, crush, chew, or dissolve. label ↗

    12 labels read

  • Can you crush Darifenacin?

    Swallow whole — the label says not to crush or chew it · Darifenacin

    Do not chew, cut or crush darifenacin extended-release tablet. label ↗

    10 labels read

  • Can you crush Dasatinib?

    Swallow whole — the label says not to crush or chew it · Dasatinib

    Do not crush, cut or chew tablets. label ↗

    16 labels read

  • Can you crush Desvenlafaxine?

    Swallow whole — the label says not to crush or chew it · Pristiq Extended-Release

    Take tablets whole; do not divide, crush, chew, or dissolve. label ↗

    46 labels read

  • Can you crush Dexmethylphenidate?

    Swallow whole — the label says not to crush or chew it · Dexmethylphenidate Hydrochloride

    The dose of a single capsule should not be divided. label ↗

    42 labels read

  • Can you crush Diethylpropion?

    Swallow whole — the label says not to crush or chew it · Diethylpropion Hydrochloride ER

    Diethylpropion Hydrochloride Extended Release Tablets, 75 mg: One extended-release 75 mg tablet daily, swallowed whole, in midmorning. label ↗

    23 labels read

  • Can you crush Diflunisal?

    Swallow whole — the label says not to crush or chew it · Diflunisal

    Tablets should be swallowed whole, not crushed or chewed. label ↗

    6 labels read

  • Can you crush Diltiazem?

    Swallow whole — the label says not to crush or chew it · Diltiazem Hydrochloride

    Do not split diltiazem tablets. label ↗

    50 labels read

  • Can you crush Dimethyl?

    Swallow whole — the label says not to crush or chew it · TECFIDERA

    TECFIDERA should be swallowed whole and intact. label ↗

    30 labels read

  • Can you crush Diphenhydramine?

    It depends on what you mean — read the sentence · Nighttime Sleep-Aid

    Warnings Do not use ■ for children under 12 years of age ■ with any other product containing diphenhydramine, even one used on skin. label ↗

    50 labels read

  • Can you crush Divalproex?

    Swallow whole — the label says not to crush or chew it · Depakote

    Depakote should be swallowed whole and should not be crushed or chewed. label ↗

    50 labels read

  • Can you crush Dolutegravir?

    Swallow whole — the label says not to crush or chew it · Tivicay

    Do not chew, cut, or crush the tablets. label ↗

    5 labels read

  • Can you crush Donepezil?

    Swallow whole — the label says not to crush or chew it · DONEPEZIL HYDROCHLORIDE

    Do not split, crush, or chew the tablets. label ↗

    50 labels read

  • Can you crush Doxazosin?

    Swallow whole — the label says not to crush or chew it · Cardura XL

    Do not chew, divide, cut, or crush CARDURA XL tablets before swallowing. label ↗

    50 labels read

  • Can you crush Doxycycline?

    Swallow whole — the label says not to crush or chew it · DOXYCYCLINE HYCLATE

    Do not chew or crush tablets [see Dosage and Administration. label ↗

    50 labels read

  • Can you crush Drospirenone?

    Swallow whole — the label says not to crush or chew it · SLYND

    How to Take SLYND SLYND (white active and green inert tablets) is swallowed whole once a day. label ↗

    32 labels read

  • Can you crush Duloxetine?

    Swallow whole — the label says not to crush or chew it · Duloxetine Delayed-Release

    Swallow whole; do not crush, chew, or open capsule. label ↗

    50 labels read

  • Can you crush Dutasteride?

    Swallow whole — the label says not to crush or chew it · Dutasteride

    Dosing considerations: Swallow whole. label ↗

    27 labels read

  • Can you crush Efavirenz?

    Swallow whole — the label says not to crush or chew it · Efavirenz

    Table 1: Efavirenz Dosing in Pediatric Patients b Tablets must not be crushed. label ↗

    16 labels read

  • Can you crush Eltrombopag Olamine?

    Swallow whole — the label says not to crush or chew it · Eltrombopag

    Do not split, chew, or crush tablets and mix with food or liquids. label ↗

    6 labels read

  • Can you crush Enalapril?

    The label allows it, in the terms quoted · Enalapril maleate oral solution

    The dose may be divided and administered twice daily if the antihypertensive effect diminishes at the end of the dosing interval. label ↗

    50 labels read

  • Can you crush Erythromycin Ethylsuccinate?

    Swallow whole — the label says not to crush or chew it · ERYTHROMYCIN ETHYLSUCCINATE

    To avoid unpleasant taste, the 400 mg tablets should not be chewed. label ↗

    15 labels read

  • Can you crush Esomeprazole?

    Swallow whole — the label says not to crush or chew it · Acid Reducer

    Do not crush or chew capsules. label ↗

    50 labels read

  • Can you crush Everolimus?

    Swallow whole — the label says not to crush or chew it · Everolimus

    Do not break or crush tablets. label ↗

    21 labels read

  • Can you crush Felodipine?

    Swallow whole — the label says not to crush or chew it · Felopdipine

    Felodipine should be swallowed whole and not crushed or chewed. label ↗

    33 labels read

  • Can you crush Fenofibrate?

    Swallow whole — the label says not to crush or chew it · FENOFIBRATE

    Do not crush, dissolve or chew tablets. label ↗

    50 labels read

  • Can you crush Ferric?

    Swallow whole — the label says not to crush or chew it · Auryxia

    Auryxia tablets must not be chewed or crushed because it may cause discoloration of mouth and teeth. label ↗

    41 labels read

  • Can you crush Fluvastatin?

    Swallow whole — the label says not to crush or chew it · Lescol XL

    Do not break, crush or chew LESCOL XL tablets. label ↗

    11 labels read

  • Can you crush Gabapentin?

    Swallow whole — the label says not to crush or chew it · GABAPENTIN

    Do not crush, split, or chew the tablets. label ↗

    50 labels read

  • Can you crush Glipizide?

    Swallow whole — the label says not to crush or chew it · Glipizide

    Do not break, crush, dissolve, chew, or cut the tablet in half. label ↗

    50 labels read

  • Can you crush Granisetron?

    Swallow whole — the label says not to crush or chew it · SANCUSO

    Do not cut the transdermal system. label ↗

    10 labels read

  • Can you crush Guanfacine?

    Swallow whole — the label says not to crush or chew it · Intuniv

    Do not crush, chew, or break INTUNIV. label ↗

    50 labels read

  • Can you crush Ibandronate?

    Swallow whole — the label says not to crush or chew it · IBANDRONATE SODIUM

    Do not chew or suck the tablet because of a potential for oropharyngeal ulceration. label ↗

    10 labels read

  • Can you crush Icosapent Ethyl?

    Swallow whole — the label says not to crush or chew it · Vascepa

    Do not break open, crush, dissolve, or chew VASCEPA. label ↗

    30 labels read

  • Can you crush Imatinib?

    Swallow whole — the label says not to crush or chew it · Imatinib Mesylate

    Do not crush imatinib mesylate tablets. label ↗

    The label allows it, in the terms quoted · Gleevec

    Gleevec treatment can be given as a once daily dose or the daily dose may be split into two–one portion dosed in the morning and one portion in the evening. label ↗

    25 labels read

  • Can you crush Iodide?

    The label allows it, in the terms quoted · Thyrosafe

    Tablets can be crushed and mixed in many liquids. label ↗

    50 labels read

  • Can you crush Isosorbide Mononitrate?

    Swallow whole — the label says not to crush or chew it · Isosorbide Mononitrate

    Do not break the 30 mg tablet. label ↗

    38 labels read

  • Can you crush Isotretinoin?

    Swallow whole — the label says not to crush or chew it · Isotretinoin

    Do not split, crush, chew, or suck on the capsules. label ↗

    21 labels read

  • Can you crush Itraconazole?

    Swallow whole — the label says not to crush or chew it · Tolsura

    TOLSURA capsules must be swallowed whole. label ↗

    15 labels read

  • Can you crush Ketoconazole?

    Swallow whole — the label says not to crush or chew it · Ketodan

    Do not break through (puncture) the Ketodan ® Foam, 2% can. label ↗

    50 labels read

  • Can you crush Lacosamide?

    Swallow whole — the label says not to crush or chew it · Lacosamide

    Do not cut lacosamide tablets. label ↗

    50 labels read

  • Can you crush Lamotrigine?

    Swallow whole — the label says not to crush or chew it · Lamotrigine

    Tablets must be swallowed whole and must not be chewed, crushed, or divided. label ↗

    50 labels read

  • Can you crush Lansoprazole?

    Swallow whole — the label says not to crush or chew it · Lansoprazole

    Do not crush or chew capsules. label ↗

    50 labels read

  • Can you crush Lenalidomide?

    Swallow whole — the label says not to crush or chew it · Revlimid

    REVLIMID should be swallowed whole with water. label ↗

    21 labels read

  • Can you crush Levetiracetam?

    Swallow whole — the label says not to crush or chew it · Keppra

    KEPPRA tablets should be swallowed whole. label ↗

    50 labels read

  • Can you crush Levothyroxine?

    The label allows it, in the terms quoted · Levothyroxine Sodium

    Levothyroxine Sodium Tablets, USP may be administered to infants and children who cannot swallow intact tablets by crushing the tablet and suspending the freshly crushed tablet in a small amount (5-10 mL or 1-2 teaspoons) of water. label ↗

    50 labels read

  • Can you crush Lisdexamfetamine Dimesylate?

    Swallow whole — the label says not to crush or chew it · Lisdexamfetamine Dimesylate

    A single dose should not be divided. label ↗

    29 labels read

  • Can you crush Lithium?

    Swallow whole — the label says not to crush or chew it · Lithium Carbonate

    Lithium carbonate extended-release tablets must be swallowed whole and never chewed or crushed. label ↗

    50 labels read

  • Can you crush Lomustine?

    Swallow whole — the label says not to crush or chew it · Gleostine

    Do not break Gleostine capsules; avoid exposure to broken capsules. label ↗

    4 labels read

  • Can you crush Lorazepam?

    Swallow whole — the label says not to crush or chew it · LOREEV XR

    Do not crush or chew LOREEV XR. label ↗

    50 labels read

  • Can you crush Lubiprostone?

    Swallow whole — the label says not to crush or chew it · Lubiprostone

    Swallow capsules whole and do not break apart or chew. label ↗

    25 labels read

  • Can you crush Meclizine?

    Swallow whole — the label says not to crush or chew it · Meclizine Hydrochloride

    Instructions Meclizine hydrochloride tablets must be swallowed whole. label ↗

    50 labels read

  • Can you crush Mefloquine?

    It depends on what you mean — read the sentence · Mefloquine Hydrochloride

    The tablets may be crushed and suspended in a small amount of water, milk or other beverage for administration to small children and other persons unable to swallow them whole. label ↗

    3 labels read

  • Can you crush Memantine?

    Swallow whole — the label says not to crush or chew it · Memantine Hydrochloride

    The capsules should not be divided, chewed or crushed. label ↗

    50 labels read

  • Can you crush Mesalamine?

    Swallow whole — the label says not to crush or chew it · Mesalamine

    Do not cut or break the suppository. label ↗

    50 labels read

  • Can you crush Metformin?

    Swallow whole — the label says not to crush or chew it · Metformin hydrochloride

    Do not crush, cut, or chew the tablets. label ↗

    50 labels read

  • Can you crush Methadone?

    Swallow whole — the label says not to crush or chew it · METHADOSE DISPERSIBLE

    The tablets should not be chewed or swallowed before dispersing in liquid. label ↗

    35 labels read

  • Can you crush Methylphenidate?

    Swallow whole — the label says not to crush or chew it · RELEXXII

    Do not chew, divide, or crush. label ↗

    50 labels read

  • Can you crush Metoprolol?

    It depends on what you mean — read the sentence · Metoprolol Succinate

    Metoprolol succinate extended-release tablets are scored and can be divided; however, do not crush or chew the whole or half tablet. label ↗

    50 labels read

  • Can you crush Mifepristone?

    Swallow whole — the label says not to crush or chew it · Korlym

    Do not split, crush, or chew tablets. label ↗

    5 labels read

  • Can you crush Minocycline?

    Swallow whole — the label says not to crush or chew it · MINOCYCLINE HYDROCHLORIDE

    The tablets should be swallowed whole. label ↗

    50 labels read

  • Can you crush Mirabegron?

    Swallow whole — the label says not to crush or chew it · MIRABEGRON

    Do not chew, divide, or crush. label ↗

    14 labels read

  • Can you crush Morphine?

    Swallow whole — the label says not to crush or chew it · Morphine sulfate

    Do not crush, chew, or dissolve the tablets [see Dosage and Administration. label ↗

    50 labels read

  • Can you crush Mycophenolate Mofetil?

    Swallow whole — the label says not to crush or chew it · Mycophenolate Mofetil

    Mycophenolate mofetil tablets should not be crushed. label ↗

    47 labels read

  • Can you crush Nevirapine?

    Swallow whole — the label says not to crush or chew it · NEVIRAPINE

    They must not be chewed, crushed, or divided. label ↗

    9 labels read

  • Can you crush Nicotine?

    Swallow whole — the label says not to crush or chew it · Kirkland Signature Nicotine

    Do not chew or swallow lozenge. label ↗

    50 labels read

  • Can you crush Nicotine Polacrilex?

    Swallow whole — the label says not to crush or chew it · Nicotine Polacrilex

    Do not chew or swallow lozenge. label ↗

    50 labels read

  • Can you crush Nifedipine?

    Swallow whole — the label says not to crush or chew it · Nifedipine

    Do not chew, divide or crush tablets. label ↗

    50 labels read

  • Can you crush Nilotinib?

    Swallow whole — the label says not to crush or chew it · DANZITEN

    Do not cut, crush, or chew the tablets. label ↗

    11 labels read

  • Can you crush Nimodipine?

    Swallow whole — the label says not to crush or chew it · nimodipine

    In general, the capsules should be swallowed whole with a little liquid, preferably not less than one hour before or two hours after meals. label ↗

    4 labels read

  • Can you crush Nintedanib?

    Swallow whole — the label says not to crush or chew it · nintedanib

    3) ] and swallowed whole with liquid. label ↗

    11 labels read

  • Can you crush Nitisinone?

    The label allows it, in the terms quoted · NITYR

    For patients who can swallow semi-solid foods, NITYR tablets can be crushed and mixed with applesauce. label ↗

    10 labels read

  • Can you crush Nitroglycerin?

    Swallow whole — the label says not to crush or chew it · Nitroglycerin

    Do not chew, crush, or swallow nitroglycerin sublingual tablets. label ↗

    50 labels read

  • Can you crush Omega-3-Acid Ethyl Esters?

    Swallow whole — the label says not to crush or chew it · Lovaza

    Do not break open, crush, dissolve, or chew LOVAZA. label ↗

    26 labels read

  • Can you crush Omeprazole?

    Swallow whole — the label says not to crush or chew it · omeprazole

    Do not chew or crush capsules. label ↗

    50 labels read

  • Can you crush Oxcarbazepine?

    Swallow whole — the label says not to crush or chew it · Oxcarbazepine

    Do not cut, chew, or crush the tablet. label ↗

    50 labels read

  • Can you crush Oxybutynin?

    Swallow whole — the label says not to crush or chew it · OXYTROL

    Do not divide or cut the patch into pieces. label ↗

    50 labels read

  • Can you crush Oxybutynin Chloride?

    Swallow whole — the label says not to crush or chew it · Oxybutynin Chloride Extended Release

    Patients should be informed that Oxybutynin chloride extended-release tablets should be swallowed whole with the aid of liquids. label ↗

    50 labels read

  • Can you crush Palbociclib?

    Swallow whole — the label says not to crush or chew it · Ibrance

    Do not chew, crush or split IBRANCE tablets before swallowing them. label ↗

    3 labels read

  • Can you crush Paliperidone?

    Swallow whole — the label says not to crush or chew it · INVEGA HAFYERA

    Do not divide dose into multiple injections. label ↗

    29 labels read

  • Can you crush Pantoprazole?

    Swallow whole — the label says not to crush or chew it · Pantoprazole Sodium

    Do not split, crush, or chew pantoprazole sodium delayed-release tablets. label ↗

    50 labels read

  • Can you crush Pazopanib?

    Swallow whole — the label says not to crush or chew it · Pazopanib

    Do not crush tablets due to the potential for increased rate of absorption, which may affect systemic exposure [see Clinical Pharmacology. label ↗

    9 labels read

  • Can you crush Phenylbutyrate?

    Swallow whole — the label says not to crush or chew it · PHEBURANE

    Do not chew PHEBURANE oral pellets directly or mix into liquids. label ↗

    15 labels read

  • Can you crush Phenytoin?

    Swallow whole — the label says not to crush or chew it · Dilantin Infatabs

    DILANTIN INFATABS can be either chewed thoroughly before being swallowed or swallowed whole. label ↗

    50 labels read

  • Can you crush Piroxicam?

    The label allows it, in the terms quoted · Piroxicam

    If desired, the daily dose may be divided. label ↗

    17 labels read

  • Can you crush Pomalidomide?

    Swallow whole — the label says not to crush or chew it · Pomalidomide

    Do not break, chew, or open the capsules. label ↗

    7 labels read

  • Can you crush Posaconazole?

    Swallow whole — the label says not to crush or chew it · posaconazole

    Do not divide, crush, or chew. label ↗

    34 labels read

  • Can you crush Pramipexole?

    Swallow whole — the label says not to crush or chew it · Pramipexole dihydrochloride

    Tablets must be swallowed whole and must not be chewed, crushed, or divided. label ↗

    37 labels read

  • Can you crush Prednisolone?

    Swallow whole — the label says not to crush or chew it · Orapred ODT

    Do not break or use partial Orapred ODT tablets. label ↗

    50 labels read

  • Can you crush Prednisone?

    Swallow whole — the label says not to crush or chew it · Prednisone delayed release

    Prednisone delayed-release tablets should be swallowed whole and not broken, divided, or chewed. label ↗

    50 labels read

  • Can you crush Pregabalin?

    Swallow whole — the label says not to crush or chew it · Pregabalin Extended Release

    It should be swallowed whole and should not be split, crushed, or chewed. label ↗

    50 labels read

  • Can you crush Propafenone?

    Swallow whole — the label says not to crush or chew it · Propafenone Hydrochloride

    Do not crush or further divide the contents of the capsule. label ↗

    28 labels read

  • Can you crush Quetiapine?

    Swallow whole — the label says not to crush or chew it · Quetiapine Extended Release

    Swallow tablets whole and do not split, chew or crush. label ↗

    50 labels read

  • Can you crush Rabeprazole?

    Swallow whole — the label says not to crush or chew it · Rabeprazole Sodium

    Do not chew, crush or split tablets. label ↗

    37 labels read

  • Can you crush Raltegravir?

    Swallow whole — the label says not to crush or chew it · ISENTRESS

    ISENTRESS film-coated tablets must be swallowed whole. label ↗

    It depends on what you mean — read the sentence · ISENTRESS

    ISENTRESS chewable tablets may be chewed or swallowed whole. label ↗

    The label allows it, in the terms quoted · ISENTRESS

    Additionally, the 25 mg chewable tablet may be crushed. label ↗

    5 labels read

  • Can you crush Ramelteon?

    Swallow whole — the label says not to crush or chew it · Ramelteon

    Do not break the tablet; it should be swallowed whole. label ↗

    41 labels read

  • Can you crush Ranolazine?

    Swallow whole — the label says not to crush or chew it · ASPRUZYO SPRINKLE

    Do not crush or chew the granules. label ↗

    32 labels read

  • Can you crush Rilpivirine?

    Swallow whole — the label says not to crush or chew it · EDURANT

    Do not crush, chew, or swallow whole EDURANT PED tablets for oral suspension. label ↗

    9 labels read

  • Can you crush Risedronate?

    Swallow whole — the label says not to crush or chew it · Atelvia

    Do not chew, cut, or crush Atelvia tablets. label ↗

    13 labels read

  • Can you crush Ritonavir?

    Swallow whole — the label says not to crush or chew it · Ritonavir

    Do not chew, break, or crush tablets before swallowing. label ↗

    14 labels read

  • Can you crush Rivaroxaban?

    Swallow whole — the label says not to crush or chew it · Xarelto

    For children who are unable to swallow whole tablets, XARELTO oral suspension may be used. label ↗

    It depends on what you mean — read the sentence · RIVAROXABAN

    Options For adult patients who are unable to swallow whole tablets, rivaroxaban tablets may be crushed and mixed with applesauce immediately prior to use and administered orally. label ↗

    The label allows it, in the terms quoted · RIVAROXABAN

    NG) tube or gastric feeding tube: After confirming gastric placement of the tube, rivaroxaban tablets (all strengths) may be crushed and suspended in 50 mL of water and administered via an NG tube or gastric feeding tube. label ↗

    27 labels read

  • Can you crush Rivastigmine?

    Swallow whole — the label says not to crush or chew it · Rivastigmine

    Figure C • Do not cut or fold the rivastigmine transdermal system itself. label ↗

    29 labels read

  • Can you crush Rosuvastatin?

    Swallow whole — the label says not to crush or chew it · Rosuvastatin Calcium

    The tablet should be swallowed whole. label ↗

    50 labels read

  • Can you crush Sapropterin?

    Swallow whole — the label says not to crush or chew it · Kuvan

    Advise patients and caregivers: KUVAN tablets can be swallowed whole, dissolved in water or apple juice, or crushed and mixed with a small amount of soft food such as apple sauce or pudding. label ↗

    16 labels read

  • Can you crush Saxagliptin?

    Swallow whole — the label says not to crush or chew it · Saxagliptin

    Do not cut, crush, or chew saxagliptin tablets. label ↗

    6 labels read

  • Can you crush Scopolamine?

    Swallow whole — the label says not to crush or chew it · Scopolamine

    Do not cut the transdermal system. label ↗

    25 labels read

  • Can you crush Selegiline?

    Swallow whole — the label says not to crush or chew it · EMSAM

    Do not cut the EMSAM transdermal system into smaller portions. label ↗

    15 labels read

  • Can you crush Selexipag?

    Swallow whole — the label says not to crush or chew it · UPTRAVI

    Do not split or crush the tablets. label ↗

    3 labels read

  • Can you crush Sirolimus?

    Swallow whole — the label says not to crush or chew it · sirolimus

    Tablets should not be crushed, chewed or split. label ↗

    26 labels read

  • Can you crush Solifenacin?

    Swallow whole — the label says not to crush or chew it · VESIcare

    VESIcare should be taken with water and swallowed whole. label ↗

    35 labels read

  • Can you crush Tacrolimus?

    Swallow whole — the label says not to crush or chew it · Envarsus XR

    Do not chew, divide or crush tablet. label ↗

    47 labels read

  • Can you crush Tadalafil?

    Swallow whole — the label says not to crush or chew it · tadalafil

    Do not split tadalafil tablets; entire dose should be taken. label ↗

    50 labels read

  • Can you crush Tafenoquine?

    Swallow whole — the label says not to crush or chew it · Arakoda

    Do not break, crush or chew the tablets. label ↗

    3 labels read

  • Can you crush Tamsulosin?

    Swallow whole — the label says not to crush or chew it · Tamsulosin Hydrochloride

    Tamsulosin capsules should not be crushed, chewed or opened. label ↗

    50 labels read

  • Can you crush Temozolomide?

    Swallow whole — the label says not to crush or chew it · TEMOZOLOMIDE

    Advise patients that temozolomide capsules should be swallowed whole and NEVER CHEWED. label ↗

    16 labels read

  • Can you crush Tinidazole?

    The label allows it, in the terms quoted · Tindazole

    Compounding of the Oral Suspension For those unable to swallow tablets, tinidazole tablets may be crushed in artificial cherry syrup to be taken with food. label ↗

    6 labels read

  • Can you crush Tiopronin?

    The label allows it, in the terms quoted · Thiola EC

    THIOLA EC can be crushed and mixed with applesauce. label ↗

    9 labels read

  • Can you crush Tiotropium?

    Swallow whole — the label says not to crush or chew it · Tiotropium Bromide

    See Figure G) Remove the tiotropium bromide inhalation powder capsule from the blister: Do not cut the foil or use sharp instruments to take out the tiotropium bromide inhalation powder capsule from the blister. label ↗

    6 labels read

  • Can you crush Tofacitinib?

    Swallow whole — the label says not to crush or chew it · Tofacitinib

    Do not crush, split, or chew the extended-release tablets [see Clinical Pharmacology. label ↗

    28 labels read

  • Can you crush Tolterodine?

    Swallow whole — the label says not to crush or chew it · Tolterodine Tartrate

    DOSAGE AND ADMINISTRATION 4 mg capsules taken orally once daily with water and swallowed whole. label ↗

    22 labels read

  • Can you crush Topiramate?

    Swallow whole — the label says not to crush or chew it · QUDEXY XR

    Capsules may be swallowed whole or opened and sprinkled on a spoonful of soft food. label ↗

    50 labels read

  • Can you crush Topotecan?

    Swallow whole — the label says not to crush or chew it · HYCAMTIN

    Do not chew, crush, or divide the capsules. label ↗

    7 labels read

  • Can you crush Tramadol?

    Swallow whole — the label says not to crush or chew it · TRAMADOL HYDROCHLORIDE

    The tablets should not be chewed, crushed, or split. label ↗

    The label allows it, in the terms quoted · Tramadol Hydrochloride

    Tramadol hydrochloride tablets 100 mg is a scored tablet and can be split into two halves for 50 mg dose titration or administered as a whole tablet for 100 mg dose. label ↗

    50 labels read

  • Can you crush Tranexamic Acid?

    Swallow whole — the label says not to crush or chew it · Tranexamic Acid

    Swallow tablets whole; do not chew or break apart. label ↗

    48 labels read

  • Can you crush Trazodone?

    Swallow whole — the label says not to crush or chew it · Trazodone Hydrochloride

    Tablets should be swallowed whole or broken in half along the score line. label ↗

    50 labels read

  • Can you crush Treprostinil?

    Swallow whole — the label says not to crush or chew it · Orenitram

    Do not split, chew, crush, or break. label ↗

    9 labels read

  • Can you crush Tretinoin?

    Swallow whole — the label says not to crush or chew it · Tretinoin

    Do not chew, dissolve, or open capsule. label ↗

    50 labels read

  • Can you crush Trientine?

    Swallow whole — the label says not to crush or chew it · Trientine Hydrochloride

    The capsules should be swallowed whole with water and should not be opened or chewed. label ↗

    8 labels read

  • Can you crush Trihexyphenidyl?

    The label allows it, in the terms quoted · Trihexyphenidyl Hydrochloride

    High doses (>10 mg daily) may be divided into 4 parts, with 3 doses administered at mealtimes and the fourth at bedtime. label ↗

    13 labels read

  • Can you crush Valganciclovir?

    Swallow whole — the label says not to crush or chew it · Valcyte

    Do not break or crush VALCYTE tablets. label ↗

    27 labels read

  • Can you crush Valproic Acid?

    Swallow whole — the label says not to crush or chew it · Valproic

    Valproic Acid capsules should be swallowed whole without chewing to avoid local irritation of the mouth and throat. label ↗

    23 labels read

  • Can you crush Venlafaxine?

    Swallow whole — the label says not to crush or chew it · Venlafaxine Hydrochloride

    Do not divide, crush, chew, or place in water. label ↗

    50 labels read

  • Can you crush Verapamil?

    Swallow whole — the label says not to crush or chew it · Verapamil Hydrochloride

    Verapamil Hydrochloride Extended-release Capsules (PM) SHOULD NOT BE CRUSHED OR CHEWED. label ↗

    50 labels read

  • Can you crush Zileuton?

    Swallow whole — the label says not to crush or chew it · Zileuton

    Tablets should not be chewed, cut or crushed. label ↗

    6 labels read

  • Can you crush Ziprasidone?

    Swallow whole — the label says not to crush or chew it · ziprasidone

    Do not chew, crush, or open the capsules. label ↗

    41 labels read

  • Can you crush Zolmitriptan?

    Swallow whole — the label says not to crush or chew it · Zolmitriptan OD

    Do not break zolmitriptan orally disintegrating tablets. label ↗

    27 labels read

  • Can you crush Zolpidem?

    Swallow whole — the label says not to crush or chew it · ZOLPIDEM TARTRATE

    Tablets to be swallowed whole, not to be crushed, divided or chewed. label ↗

    50 labels read

  • Can you crush Zonisamide?

    Swallow whole — the label says not to crush or chew it · Zonisamide

    Capsules should be swallowed whole. label ↗

    34 labels read

Frequently asked questions

Why not just publish a 'do not crush' list?

Because a list of drug names cannot express the answer. Metoprolol succinate extended-release is, in its label's own words, "scored and can be divided; however, do not crush or chew the whole or half tablet" — permitted and forbidden in the same sentence, depending on what you are doing to it. And the immediate-release version of the same drug is a different product with different instructions. Quoting the label keeps that intact; a name on a list loses it.

Why does crushing an extended-release tablet matter so much?

Because the coating or matrix is what meters the dose out over the day. Crush it and the entire day's dose is released at once — which for an opioid, a heart-rate drug or an ADHD stimulant is the difference between a dose and an overdose. That mechanism, not the molecule, is why the instruction exists.

What if a drug isn't listed here?

It means none of the labels we read prints an instruction about crushing or splitting. Those pages exist and say so with the number of labels checked, but they are not submitted for indexing because the text is necessarily the same for every such drug. Absence of a restriction is also not a technique guide — an unscored tablet still splits unevenly.

I can't swallow tablets. What should I do?

Ask the prescriber or pharmacist before altering anything. Most drugs that cannot be crushed exist in another form — a liquid, a dispersible tablet, a patch, or an immediate-release version taken more often — and switching is usually straightforward.

Reference information quoted from FDA labels, not medical advice. Never alter a tablet against its label to make it easier to take — an alternative form usually exists, and a pharmacist can arrange it.