Which pills you can crush or split
Quoted from each drug’s own FDA label, per product — because the answer belongs to the form, not the drug name. An extended-release tablet releases a whole day’s dose at once when it is crushed; the immediate-release version of the same drug often carries no restriction at all.
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Frequently asked questions
Why not just publish a 'do not crush' list?
Because a list of drug names cannot express the answer. Metoprolol succinate extended-release is, in its label's own words, "scored and can be divided; however, do not crush or chew the whole or half tablet" — permitted and forbidden in the same sentence, depending on what you are doing to it. And the immediate-release version of the same drug is a different product with different instructions. Quoting the label keeps that intact; a name on a list loses it.
Why does crushing an extended-release tablet matter so much?
Because the coating or matrix is what meters the dose out over the day. Crush it and the entire day's dose is released at once — which for an opioid, a heart-rate drug or an ADHD stimulant is the difference between a dose and an overdose. That mechanism, not the molecule, is why the instruction exists.
What if a drug isn't listed here?
It means none of the labels we read prints an instruction about crushing or splitting. Those pages exist and say so with the number of labels checked, but they are not submitted for indexing because the text is necessarily the same for every such drug. Absence of a restriction is also not a technique guide — an unscored tablet still splits unevenly.
I can't swallow tablets. What should I do?
Ask the prescriber or pharmacist before altering anything. Most drugs that cannot be crushed exist in another form — a liquid, a dispersible tablet, a patch, or an immediate-release version taken more often — and switching is usually straightforward.
Reference information quoted from FDA labels, not medical advice. Never alter a tablet against its label to make it easier to take — an alternative form usually exists, and a pharmacist can arrange it.