Best Azole Antifungal for aspergillosis
Top-rated pick: Voriconazole — pharmaranks score 72/100, the highest of the 9 Azole Antifungal drugs used for aspergillosis, ranked by our independent FDA recall-safety score. Compare them with all treatments for aspergillosis or the full Azole Antifungal class. Not medical advice — always consult a professional.
Quick answer: Of the 9 azole antifungal drugs we rate for aspergillosis, 4 are available as lower-cost generics, and most are kit. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for aspergillosis; the right choice depends on your situation, so confirm it with your prescriber.
How azole antifungal work
Azole antifungals block a fungal enzyme (lanosterol 14-alpha-demethylase) that the fungus needs to make ergosterol, a key building block of its cell membrane. Without enough ergosterol the membrane becomes leaky and unstable, which stops the fungus from growing and can cause it to break apart and die.
Source: Antifungal Ergosterol Synthesis Inhibitors — StatPearls, NCBI Bookshelf (NIH)
Top azole antifungal for aspergillosis: 1. Voriconazole · 2. Monistat 3 · 3. Monistat 3 Combination Pack
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Generic | $56 | View → | |
| 2 | 70/100 | Over-the-counter | Kit | No data | — | View → | |
| 3 | 70/100 | Over-the-counter | Kit | No data | — | View → | |
| 4 | 70/100 | Over-the-counter | Kit | No data | — | View → | |
| 5 | 70/100 | Over-the-counter | Suppository | No data | — | View → | |
| 6 | 70/100 | Over-the-counter | Suppository | No data | — | View → | |
| 7 | 70/100 | Prescription | Capsule | Generic | $1 | View → | |
| 8 | 64/100 | Prescription | Injectable | Generic | $56 | View → | |
| 9 | Not yet rated | Prescription | Tablet | Generic | $0 | View → |
Full ranking · 9 drugs
voriconazole
PrescriptionFDA-sourced
Voriconazole is an azole antifungal used to treat Aspergillosis, Candidiasis, Fusariosis.
Pharmacy pays
From ~$11.91/30· 3 formsmonistat 3
Over-the-counterFDA-sourced
Monistat 3 (Miconazole Nitrate) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
monistat 3 combination pack
Over-the-counterFDA-sourced
Monistat 3 Combination Pack (Miconazole Nitrate) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
monistat 3 combination pack (prefilled)
Over-the-counterFDA-sourced
Monistat 3 Combination Pack (Prefilled) (Miconazole Nitrate) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
monistat 7
Over-the-counterFDA-sourced
Monistat 7 (Miconazole Nitrate) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
monistat 7 combination pack
Over-the-counterFDA-sourced
Monistat 7 Combination Pack (Miconazole Nitrate) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
tolsura
Boxed warningPrescriptionFDA-sourced
Tolsura (Itraconazole) is an azole antifungal used to treat Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis.
Pharmacy pays
From ~$0.83· 2 forms Save up to 75% in class
vfend
PrescriptionFDA-sourced
Vfend (Voriconazole) is an azole antifungal used to treat Aspergillosis, Candidiasis, Fusariosis.
Pharmacy pays
From ~$11.91/30· 3 formsoravig
PrescriptionFDA-sourced
Oravig (Miconazole) is an azole antifungal used to treat Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
Pharmacy pays
From ~$0.12· 7 formsFrequently asked
- What is the best azole antifungal for aspergillosis?
- By our independent recall-safety rating — not an efficacy measure — voriconazole ranks highest among Azole Antifungal drugs used for aspergillosis. Always consult a professional.
- Which azole antifungal drugs treat aspergillosis?
- pharmaranks lists 9 Azole Antifungal products used for aspergillosis, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.