Azole antifungals compared

Compare all 20 azole antifungals side by side, used for conditions such as candidiasis, cutaneous, candidiasis, oral, candidiasis, vulvovaginal. Azole antifungals are the Azole Antifungal class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is clotrimazole.

11 of 20 drugs in this class carry a pharmaranks safety score, ranging 56–72 out of 100 — computed from FDA recall records, not from reviews.

Rated against independent sources·Last updated June 7, 2026·How we rate

Top-rated azole antifungal: 1. Clotrimazole · 2. Ketoconazole · 3. Monistat 3

Azole Antifungal drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Clotrimazole	—	Topical	Prescription	Candidiasis, Cutaneous, Candidiasis, Oral	72/100	$0
Ketoconazole	—	Tablet	Prescription	Blastomycosis, Candidiasis, Chronic Mucocutaneous	72/100	$0
Monistat 3	Miconazole Nitrate	Kit	Over-the-counter	Aspergillosis, Candidiasis, Cutaneous	72/100	—
Monistat 3 Combination Pack	Miconazole Nitrate	Kit	Over-the-counter	Aspergillosis, Candidiasis, Cutaneous	72/100	—
Monistat 7	Miconazole Nitrate	Suppository	Over-the-counter	Aspergillosis, Candidiasis, Cutaneous	72/100	—
Monistat 7 Combination Pack	Miconazole Nitrate	Suppository	Over-the-counter	Aspergillosis, Candidiasis, Cutaneous	72/100	—
Tolsura	Itraconazole	Capsule	Prescription	Aspergillosis, Blastomycosis	72/100	$1
Voriconazole	—	Injectable	Prescription	Aspergillosis, Candidiasis	72/100	$56
Nizoral Anti-Dandruff	Ketoconazole	Topical	Over-the-counter	Blastomycosis, Candidiasis, Chronic Mucocutaneous	70/100	$0
Vfend	Voriconazole	Injectable	Prescription	Aspergillosis, Candidiasis	60/100	$56
Diflucan	Fluconazole	Suspension	Prescription	Blastomycosis, Candidiasis, Chronic Mucocutaneous	56/100	$0
Clotic	Clotrimazole	Liquid	Prescription	Candidiasis, Cutaneous, Candidiasis, Oral	Not yet rated	$0

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best azole antifungal by condition

for cutaneous candidiasis for oral candidiasis for vulvovaginal candidiasis for tinea pedis for blastomycosis for chronic mucocutaneous candidiasis

Full ranking · 20 drugs

Frequently asked questions

What is the Azole Antifungal drug class?

Azole Antifungal is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 20 Azole Antifungal products, each independently rated.

Are all Azole Antifungal drugs the same?

No. Azole Antifungal drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "azole antifungals" the same as the Azole Antifungal class?

Yes — "azole antifungals" is the everyday name for the Azole Antifungal drug class. This page compares the 20 azole antifungals pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do Azole Antifungal drugs treat?

Per NIH RxClass drug-classification data, Azole Antifungal drugs are used for conditions including candidiasis, cutaneous, candidiasis, oral, candidiasis, vulvovaginal, tinea pedis, blastomycosis, candidiasis, chronic mucocutaneous.

Which Azole Antifungal drug is best-rated?

By our independent rating, clotrimazole currently ranks highest among Azole Antifungal drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Azole Antifungal class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Antifungal Ergosterol Synthesis Inhibitors — StatPearls, NCBI Bookshelf (NIH). Ratings are pharmaranks’ independent FDA recall-safety analysis.