clotic
Clotic (Clotrimazole) is an azole antifungal used to treat Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis, Tinea Pedis.
Clotrimazole · by Carwin Pharm Assoc
Available as a generic: Clotrimazole
Key facts
- Active ingredient
- Clotrimazole
- Drug class
- Azole Antifungal
- Form
- Liquid
- Strength
- Clotrimazole 1%
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- Manufacturer
- Carwin Pharm Assoc
- What the pharmacy pays
- ~$0.21 per ml — not your price
- FDA application
- NDA217628
What is Clotic?
From the FDA label:CLOTIC is a sterile preservative-free otic solution containing clotrimazole, an azole antifungal agent, at a concentration of 1% in polyethylene glycol (PEG) 400. The solution is clear colorless to slightly yellow. Each single-dose vial of CLOTIC delivers approximately 0.17 mL of solution equivalent to 1.7 mg of clotrimazole. Chemically, clotrimazole is 1-(o-chloro-α,α-diphenylbenzyl)imidazole, with the empirical formula C 22 H 17 ClN 2 , a molecular weight of 344.84, and the following structural formula. Chemical Structure
How to use
CLOTIC is for otic use only. ( 2 ) Instill the contents of one single-dose CLOTIC vial into the affected ear canal twice daily, morning and evening, preferably 12 hours apart for 14 consecutive days. ( 2 ) See full prescribing information for preparation and administration instructions 2.1 Recommended Dosage and Administration CLOTIC is for otic use only. Instill the contents of one single-dose CLOTIC vial into the affected ear canal twice daily morning and evening, preferably 12 hours apart, for 14 consecutive days. 2.2 Preparation and Administration Instructions Warm the solution by holding the vial in the hand for 1 to 2 minutes. This is to avoid dizziness which may result from the instillation of a cold solution into the ear canal. The patient should lie with the affected ear upward, and then instill the medication. Gently pull the outer ear lobe upward and outward. This will allow the ear drops to flow down into the ear canal. Maintain this position for 1 minute after the drug administration. Repeat, if necessary, for the opposite ear [see Instructions for Use ].
Side effects
The most common adverse reactions that occurred in ≥ 1 patient were headache, application site pain, tinnitus, tympanic membrane perforation, and paresthesia. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Carwin Pharmaceutical Associates, LLC at phone 1-844-700-5011 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In two randomized, placebo-controlled, phase 3 trials, 393 adult patients with otomycosis and intact tympanic membranes were treated with CLOTIC or placebo (Trial 1 and Trial 2) twice daily for a median duration of 14 days. There were 261 patients who received at least one dose of CLOTIC and 132 patients received at least one dose of placebo. These patients had a mean age of 51 years (range 19 to 89 years); 55% were male, 87% were White, and 26% were Hispanic or Latino ethnicity. Adverse Reactions Leading to Discontinuation Treatment discontinuation due to an adverse reaction occurred in 1% (3/261) of patients receiving CLOTIC and 3% (4/132) of patients receiving placebo. Adverse reactions leading to discontinuation of CLOTIC were application site pain in two patients…
Warnings
Important safety information
None. None. ( 5 )
Who should not take Clotic
CLOTIC is contraindicated in patients with known hypersensitivity to clotrimazole. CLOTIC is contraindicated in patients with known hypersensitivity to clotrimazole. ( 4 )
Drug class
How this class works, per Antifungal Ergosterol Synthesis Inhibitors — StatPearls, NCBI Bookshelf (NIH).
May treat (source: NIH RxClass)
See how Clotic ranks — best-rated azole antifungal for:
Dosage forms
Liquid
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Clotic treat?
- Clotic (Clotrimazole) may be used to treat cutaneous candidiasis, oral candidiasis, vulvovaginal candidiasis, tinea pedis, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Clotic work?
- Clotic is a azole antifungal. Azole antifungals block a fungal enzyme (lanosterol 14-alpha-demethylase) that the fungus needs to make ergosterol, a key building block of its cell membrane. Without enough ergosterol the membrane becomes leaky and unstable, which stops the fungus from growing and can cause it to break apart and die.
- How much does Clotic cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.21 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Clotic?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Clotic. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Clotic?
- Clotic is marketed by Carwin Pharm Assoc. You can see Carwin Pharm Assoc's full profile, rating, and other products on pharmaranks.
- Is Clotic a brand-name or generic drug?
- Clotic is a brand-name product with the active ingredient Clotrimazole. Lower-cost generic equivalents containing Clotrimazole are available — ask your pharmacist.
- Is Clotic available over the counter?
- No. Clotic is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Clotic come in?
- Clotic is currently marketed as liquid, per the FDA's National Drug Code Directory.
- What class of drug is Clotic?
- Clotic is classified as azole antifungal, per the FDA's Established Pharmacologic Class.
- Is Clotic FDA-registered?
- Clotic is on record with the U.S. FDA under application number NDA217628. You can verify this on its official FDA label.
- Is Clotic safe?
- There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Clotic. Review its FDA-label side effects and warnings below, and always consult a licensed professional.
- What are the side effects of Clotic?
- Clotic's side effects are taken directly from its FDA label. From the label: The most common adverse reactions that occurred in ≥ 1 patient were headache, application site pain, tinnitus, tympanic membrane perforation, and paresthesia. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Carwin Pharmaceutical Associates,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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