CLOTRIMAZOLE vs ONMEL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. CLOTRIMAZOLE and ONMEL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOTRIMAZOLE	ONMEL
Rating	70/100	New
Pharmacy pays	$0.21 /mL	$0.84 /mL
Type	RX	RX
Active ingredient	CLOTRIMAZOLE	ITRACONAZOLE
Manufacturer	Fougera Pharms	Sebela Ireland Ltd
Dosage forms	Topical, Lozenge, Solution, Spray/Inhaler	Tablet
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

clotrimazole onmel

Rating

70/100

New

Pharmacy pays

$0.21 /mL

$0.84 /mL

Type

Active ingredient

CLOTRIMAZOLE

ITRACONAZOLE

Manufacturer

Fougera Pharms

Sebela Ireland Ltd

Dosage forms

Topical, Lozenge, Solution, Spray/Inhaler

Tablet

Drug class

Azole Antifungal

Boxed warning

None

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

Which is cheaper, Clotrimazole or Onmel?

Clotrimazole costs pharmacies less to acquire — about $0.21 vs $0.84 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clotrimazole and Onmel?

Clotrimazole contains Clotrimazole, while Onmel contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.