promethazine hydrochloride

How long does Promethazine Hydrochloride stay in your body?

The elimination half-life of promethazine hydrochloride is about 9 to 16 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Kinetics are linear (no saturable/dose-dependent behavior). The FDA label reports a plasma half-life of 9-16 hours after IV dosing and a mean of 9.8 ± 3.4 hours after IM dosing; the oral tablet label omits a numeric half-life but describes the same disposition. Duration of clinical effect (about 4-6 hours, occasionally up to 12) is shorter than the elimination half-life, so sedation can wear off well before the drug clears. Promethazine is metabolized in the liver to sulfoxides of promethazine and N-desmethylpromethazine (the main urinary metabolites); the label does not characterize these as clinically active or as outlasting the parent. Not a prodrug. Because clearance is hepatic, impaired liver function may prolong the half-life; the label gives no specific age- or kidney-based half-life values.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Promethazine Hydrochloride Injection, USP — FDA label (DailyMed).

Frequently asked questions

What does Promethazine Hydrochloride treat?

Promethazine Hydrochloride (Promethazine Hydrochloride) may be used to treat anaphylaxis, allergic conjunctivitis, motion sickness, nausea, pain, postoperative complications, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How much does Promethazine Hydrochloride cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.53 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Promethazine Hydrochloride?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Promethazine Hydrochloride. To pay less, Promethazine Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Promethazine Hydrochloride?

Promethazine Hydrochloride is marketed by Sun Pharm Inds Inc. You can see Sun Pharm Inds Inc's full profile, rating, and other products on pharmaranks.

Is Promethazine Hydrochloride a brand-name or generic drug?

Promethazine Hydrochloride is a generic medication; its active ingredient is Promethazine Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Promethazine Hydrochloride available over the counter?

No. Promethazine Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Promethazine Hydrochloride come in?

Promethazine Hydrochloride is currently marketed as injectable, solution, syrup and tablet, per the FDA's National Drug Code Directory.

What class of drug is Promethazine Hydrochloride?

Promethazine Hydrochloride is classified as phenothiazine, per the FDA's Established Pharmacologic Class.

Is Promethazine Hydrochloride FDA-registered?

Promethazine Hydrochloride is on record with the U.S. FDA under application number ANDA040863. You can verify this on its official FDA label.