What is the best phenothiazine for anaphylaxis?

By our independent rating, promethazine plain currently ranks highest among Phenothiazine drugs used for anaphylaxis. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Which phenothiazine drugs treat anaphylaxis?

pharmaranks lists 2 Phenothiazine products indicated for anaphylaxis, per FDA drug-label data — each independently rated and ranked above.

How are these ranked?

By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Phenothiazine for anaphylaxis

2 Phenothiazine drugs indicated for anaphylaxis, ranked by our independent rating. The current highest-rated is promethazine plain. Compare them with all treatments for anaphylaxis or the full Phenothiazine class. Not medical advice — always consult a professional.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Top phenothiazine for anaphylaxis: 1. Promethazine Plain · 2. Promethegan

Best-rated Phenothiazine for anaphylaxis, ranked by pharmaranks score
#	Drug	Rating	Type	Typical price
1	Promethazine Plain	Not yet rated	Prescription	$2	View →
2	Promethegan	Not yet rated	Prescription	$2	View →

Full ranking · 2 drugs

promethazine plain

PrescriptionFDA-sourced

New

Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, cocoa butter, colloidal silicon dioxide, and white wax.

phenothiazinesigma-1 agonistuncompetitive n-methyl-d-aspartate receptor antagonist

Typical price

From ~$1.43/30· 8 forms

View details →

Frequently asked

What is the best phenothiazine for anaphylaxis?: By our independent rating, promethazine plain currently ranks highest among Phenothiazine drugs used for anaphylaxis. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Which phenothiazine drugs treat anaphylaxis?: pharmaranks lists 2 Phenothiazine products indicated for anaphylaxis, per FDA drug-label data — each independently rated and ranked above.
How are these ranked?: By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Phenothiazine for anaphylaxis

promethazine plain

Frequently asked

promethegan