Phenothiazine drugs compared

Compare all 6 Phenothiazine drugs side by side, used for conditions such as anxiety disorders, dementia, nausea. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is procomp.

Top-rated phenothiazine: 1. Procomp · 2. Promethegan · 3. Perphenazine

Phenothiazine drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Procomp	Prochlorperazine Maleate	Tablet	Prescription	Anxiety Disorders, Dementia	70/100	$5
Promethegan	Promethazine Hydrochloride	Suppository	Prescription	Anaphylaxis, Conjunctivitis, Allergic	70/100	$2
Perphenazine	—	Tablet	Prescription	Tourette Syndrome, Huntington Disease	68/100	$6
Prochlorperazine Edisylate	—	Injectable	Prescription	Anxiety Disorders, Dementia	Not yet rated	—
Prochlorperazine Maleate	—	Tablet	Prescription	Anxiety Disorders, Dementia	Not yet rated	$5
Promethazine Plain	Promethazine Hydrochloride	Syrup	Prescription	Anaphylaxis, Conjunctivitis, Allergic	Not yet rated	$2

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best phenothiazine by condition

for anxiety disorders for dementia for nausea for psychotic disorders for schizophrenia for vomiting

Full ranking · 6 drugs

Frequently asked questions

What is the Phenothiazine drug class?

Phenothiazine is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 6 Phenothiazine products, each independently rated.

Are all Phenothiazine drugs the same?

No. Phenothiazine drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Phenothiazine drugs treat?

Per NIH RxClass drug-classification data, Phenothiazine drugs are used for conditions including anxiety disorders, dementia, nausea, psychotic disorders, schizophrenia, vomiting.

Which Phenothiazine drug is best-rated?

By our independent rating, procomp currently ranks highest among Phenothiazine drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Phenothiazine class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.