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Best Phenothiazine for psychotic disorders

Top-rated pick: Procomp — pharmaranks score 70/100, the highest of the 4 Phenothiazine drugs used for psychotic disorders, ranked by our independent FDA recall-safety score. Compare them with all treatments for psychotic disorders or the full Phenothiazine class. Not medical advice — always consult a professional.

Quick answer: Of the 4 phenothiazine drugs we rate for psychotic disorders, 3 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for psychotic disorders; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Top phenothiazine for psychotic disorders: 1. Procomp · 2. Perphenazine · 3. Prochlorperazine Edisylate

Best-rated Phenothiazine for psychotic disorders, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$5View →
268/100$6View →
3Not yet ratedView →
4Not yet rated$5View →

Full ranking · 4 drugs

Frequently asked

What is the best phenothiazine for psychotic disorders?
By our independent recall-safety rating — not an efficacy measure — procomp ranks highest among Phenothiazine drugs used for psychotic disorders. Always consult a professional.
Which phenothiazine drugs treat psychotic disorders?
pharmaranks lists 4 Phenothiazine products used for psychotic disorders, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.