Skip to content
ppharmaranks
Menu

PERPHENAZINE vs PROMETHAZINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. PERPHENAZINE and PROMETHAZINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
New

Pharmacy pays

~$5.68 /30
~$1.53 /30

Type

RX
RX

Active ingredient

PERPHENAZINE
PROMETHAZINE HYDROCHLORIDE

Dosage forms

Tablet
Injectable, Solution, Syrup, Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

Half-life

about 9 to 16 hours

Treats

Tourette Syndrome, Huntington Disease, Nausea
Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is cheaper, Perphenazine or Promethazine Hydrochloride?

Promethazine Hydrochloride costs pharmacies less to acquire — about $1.53 vs $5.68 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Perphenazine and Promethazine Hydrochloride?

Perphenazine contains Perphenazine, while Promethazine Hydrochloride contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.