What is the best phenothiazine for motion sickness?

By our independent rating, promethazine plain currently ranks highest among Phenothiazine drugs used for motion sickness. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Which phenothiazine drugs treat motion sickness?

pharmaranks lists 2 Phenothiazine products indicated for motion sickness, per FDA drug-label data — each independently rated and ranked above.

How are these ranked?

By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Phenothiazine for motion sickness

2 Phenothiazine drugs indicated for motion sickness, ranked by our independent rating. The current highest-rated is promethazine plain. Compare them with all treatments for motion sickness or the full Phenothiazine class. Not medical advice — always consult a professional.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Top phenothiazine for motion sickness: 1. Promethazine Plain · 2. Promethegan

Best-rated Phenothiazine for motion sickness, ranked by pharmaranks score
#	Drug	Rating	Type	Typical price
1	Promethazine Plain	Not yet rated	Prescription	$2	View →
2	Promethegan	Not yet rated	Prescription	$2	View →

Full ranking · 2 drugs

promethazine plain

PrescriptionFDA-sourced

New

Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, cocoa butter, colloidal silicon dioxide, and white wax.

phenothiazinesigma-1 agonistuncompetitive n-methyl-d-aspartate receptor antagonist

Typical price

From ~$1.43/30· 8 forms

View details →

Frequently asked

What is the best phenothiazine for motion sickness?: By our independent rating, promethazine plain currently ranks highest among Phenothiazine drugs used for motion sickness. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Which phenothiazine drugs treat motion sickness?: pharmaranks lists 2 Phenothiazine products indicated for motion sickness, per FDA drug-label data — each independently rated and ranked above.
How are these ranked?: By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.

Best Phenothiazine for motion sickness

promethazine plain

Frequently asked

promethegan