rythmol

How long does Propafenone Hydrochloride stay in your body?

The elimination half-life of propafenone hydrochloride is about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the terminal elimination half-life, not the distribution phase (the label reports a separate ~5-minute distribution half-life after IV dosing). Propafenone metabolism is genetically split: the ~90% who are extensive (rapid) metabolizers clear it with a 2-10 hour half-life, but the <10% who are slow/poor metabolizers (those who do not form the 5-hydroxy metabolite) have a much longer elimination half-life of 10 to 32 hours. The drug has two ACTIVE metabolites — 5-hydroxypropafenone (via CYP2D6) and N-depropylpropafenone/norpropafenone (via CYP3A4 and CYP1A2) — both with sodium-channel activity; the label does not state their individual half-lives, so no metabolite half-life number is given here. Liver impairment: clearance is reduced and the elimination half-life is increased in significant hepatic dysfunction (bioavailability also rises sharply). The label does not state a specific half-life change for older adults or kidney impairment in the pharmacokinetics section reviewed.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Propafenone Hydrochloride Tablet — DailyMed FDA Label, Section 12.3 Pharmacokinetics.

Frequently asked questions

What does Rythmol treat?

Rythmol (Propafenone Hydrochloride) may be used to treat atrial fibrillation, supraventricular tachycardia, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Rythmol work?

Rythmol is a antiarrhythmic. Antiarrhythmics steady an irregular heartbeat by controlling the flow of sodium, potassium, or calcium ions through heart-cell channels (or blunting adrenaline's effect), which slows or normalizes the heart's electrical signals so it beats in a more regular rhythm.

How is Rythmol rated?

pharmaranks gives Rythmol a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Rythmol cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $10.51 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Amiodarone Hydrochloride — about $3.68 on the same basis.

Is there a coupon or discount for Rythmol?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Rythmol. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Rythmol?

Rythmol is marketed by Glaxosmithkline. You can see Glaxosmithkline's full profile, rating, and other products on pharmaranks.

Is Rythmol a brand-name or generic drug?

Rythmol is a brand-name product with the active ingredient Propafenone Hydrochloride. Lower-cost generic equivalents containing Propafenone Hydrochloride are available — ask your pharmacist.

Is Rythmol available over the counter?

No. Rythmol is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Rythmol come in?

Rythmol is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Rythmol?

Rythmol is classified as antiarrhythmic, per the FDA's Established Pharmacologic Class.

Is Rythmol FDA-registered?

Rythmol is on record with the U.S. FDA under application number NDA019151. You can verify this on its official FDA label.

Has Rythmol been recalled by the FDA?

Rythmol has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Rythmol safe?

There's no single safe-or-not verdict. pharmaranks gives Rythmol a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.