Best Antiarrhythmic for atrial fibrillation
Top-rated pick: Propafenone Hydrochloride — pharmaranks score 72/100, the highest of the 7 Antiarrhythmic drugs used for atrial fibrillation, ranked by our independent FDA recall-safety score. Compare them with all treatments for atrial fibrillation or the full Antiarrhythmic class. Not medical advice — always consult a professional.
Quick answer: Of the 7 antiarrhythmic drugs we rate for atrial fibrillation, 6 are available as lower-cost generics, and most are capsule. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for atrial fibrillation; the right choice depends on your situation, so confirm it with your prescriber.
How antiarrhythmic work
Antiarrhythmics steady an irregular heartbeat by controlling the flow of sodium, potassium, or calcium ions through heart-cell channels (or blunting adrenaline's effect), which slows or normalizes the heart's electrical signals so it beats in a more regular rhythm.
Source: Antiarrhythmic Medications - StatPearls - NCBI Bookshelf
Other drug classes for atrial fibrillation
Top antiarrhythmic for atrial fibrillation: 1. Propafenone Hydrochloride · 2. Corvert · 3. Norpace
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Capsule | Generic | $11 | View → | |
| 2 | 64/100 | Prescription | Injectable | No data | — | View → | |
| 3 | 64/100 | Prescription | Capsule | Generic | $25 | View → | |
| 4 | 60/100 | Prescription | Capsule | Generic | $6 | View → | |
| 5 | Not yet rated | Prescription | Tablet | Generic | $3 | View → | |
| 6 | Not yet rated | Prescription | Tablet | Generic | $3 | View → | |
| 7 | Not yet rated | Prescription | Tablet | Generic | $3 | View → |
Full ranking · 7 drugs
propafenone hydrochloride
Boxed warningPrescriptionFDA-sourced
Propafenone Hydrochloride is an antiarrhythmic used to treat Atrial Fibrillation, Supraventricular Tachycardia.
Pharmacy pays
From ~$3.34/30· 6 forms Save up to 72% in class
corvert
Boxed warningPrescriptionFDA-sourced
Corvert (Ibutilide Fumarate) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter.
Price varies
norpace
Boxed warningPrescriptionFDA-sourced
Norpace (Disopyramide Phosphate) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Ventricular Premature Complexes.
Pharmacy pays
From ~$23.78/30· 2 forms Save up to 88% in classtikosyn
Boxed warningPrescriptionFDA-sourced
Tikosyn (Dofetilide) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter.
Pharmacy pays
From ~$5.64/30· 3 forms Save up to 49% in classbetapace
Boxed warningPrescriptionFDA-sourced
Betapace (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsbetapace af
Boxed warningPrescriptionFDA-sourced
Betapace Af (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formssorine
Boxed warningPrescriptionFDA-sourced
Sorine (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsFrequently asked
- What is the best antiarrhythmic for atrial fibrillation?
- By our independent recall-safety rating — not an efficacy measure — propafenone hydrochloride ranks highest among Antiarrhythmic drugs used for atrial fibrillation. Always consult a professional.
- Which antiarrhythmic drugs treat atrial fibrillation?
- pharmaranks lists 7 Antiarrhythmic products used for atrial fibrillation, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.