Antiarrhythmic drugs compared

Compare all 10 Antiarrhythmic drugs side by side, used for conditions such as atrial fibrillation, tachycardia, supraventricular, diabetic neuropathies. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is propafenone hydrochloride.

6 of 10 drugs in this class carry a pharmaranks safety score, ranging 56–72 out of 100 — computed from FDA recall records, not from reviews.

Rated against independent sources·Last updated June 7, 2026·How we rate

Top-rated antiarrhythmic: 1. Propafenone Hydrochloride · 2. Mexiletine Hydrochloride · 3. Amiodarone Hydrochloride

Antiarrhythmic drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Propafenone Hydrochloride	—	Capsule	Prescription	Atrial Fibrillation, Tachycardia, Supraventricular	72/100	$11
Mexiletine Hydrochloride	—	Capsule	Prescription	Diabetic Neuropathies, Ventricular Fibrillation	70/100	$8
Amiodarone Hydrochloride	—	Injectable	Prescription	Tachycardia, Supraventricular, Ventricular Fibrillation	66/100	$4
Corvert	Ibutilide Fumarate	Injectable	Prescription	Atrial Fibrillation, Atrial Flutter	60/100	—
Norpace	Disopyramide Phosphate	Capsule	Prescription	Atrial Fibrillation, Atrial Flutter	58/100	$26
Tikosyn	Dofetilide	Capsule	Prescription	Atrial Fibrillation, Atrial Flutter	56/100	$6
Betapace	Sotalol Hydrochloride	Tablet	Prescription	Atrial Fibrillation, Atrial Flutter	Not yet rated	$3
Betapace Af	Sotalol Hydrochloride	Tablet	Prescription	Atrial Fibrillation, Atrial Flutter	Not yet rated	$3
Nexterone	Amiodarone Hydrochloride	Injectable	Prescription	Tachycardia, Supraventricular, Ventricular Fibrillation	Not yet rated	$4
Sorine	Sotalol Hydrochloride	Tablet	Prescription	Atrial Fibrillation, Atrial Flutter	Not yet rated	$3

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best antiarrhythmic by condition

for atrial fibrillation for supraventricular tachycardia for ventricular fibrillation for ventricular premature complexes for atrial flutter

Full ranking · 10 drugs

Frequently asked questions

What is the Antiarrhythmic drug class?

Antiarrhythmic is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 10 Antiarrhythmic products, each independently rated.

Are all Antiarrhythmic drugs the same?

No. Antiarrhythmic drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Antiarrhythmic drugs treat?

Per NIH RxClass drug-classification data, Antiarrhythmic drugs are used for conditions including atrial fibrillation, tachycardia, supraventricular, diabetic neuropathies, ventricular fibrillation, ventricular premature complexes, atrial flutter.

Which Antiarrhythmic drug is best-rated?

By our independent rating, propafenone hydrochloride currently ranks highest among Antiarrhythmic drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Antiarrhythmic class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Antiarrhythmic Medications - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.