Antiarrhythmic drugs compared
Compare all 10 Antiarrhythmic drugs side by side, used for conditions such as atrial fibrillation, tachycardia, supraventricular, diabetic neuropathies. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is propafenone hydrochloride.
Top-rated antiarrhythmic: 1. Propafenone Hydrochloride · 2. Mexiletine Hydrochloride · 3. Amiodarone Hydrochloride
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Propafenone Hydrochloride | — | Capsule | Prescription | Atrial Fibrillation, Tachycardia, Supraventricular | 72/100 | $11 |
| Mexiletine Hydrochloride | — | Capsule | Prescription | Diabetic Neuropathies, Ventricular Fibrillation | 70/100 | $8 |
| Amiodarone Hydrochloride | — | Injectable | Prescription | Tachycardia, Supraventricular, Ventricular Fibrillation | 68/100 | $4 |
| Corvert | Ibutilide Fumarate | Injectable | Prescription | Atrial Fibrillation, Atrial Flutter | 64/100 | — |
| Norpace | Disopyramide Phosphate | Capsule | Prescription | Atrial Fibrillation, Atrial Flutter | 64/100 | $25 |
| Tikosyn | Dofetilide | Capsule | Prescription | Atrial Fibrillation, Atrial Flutter | 60/100 | $6 |
| Betapace | Sotalol Hydrochloride | Tablet | Prescription | Atrial Fibrillation, Atrial Flutter | Not yet rated | $3 |
| Betapace Af | Sotalol Hydrochloride | Tablet | Prescription | Atrial Fibrillation, Atrial Flutter | Not yet rated | $3 |
| Nexterone | Amiodarone Hydrochloride | Injectable | Prescription | Tachycardia, Supraventricular, Ventricular Fibrillation | Not yet rated | $4 |
| Sorine | Sotalol Hydrochloride | Tablet | Prescription | Atrial Fibrillation, Atrial Flutter | Not yet rated | $3 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best antiarrhythmic by condition
Full ranking · 10 drugs
- 172/100
propafenone hydrochloride
Propafenone Hydrochloride
- 270/100
mexiletine hydrochloride
Mexiletine Hydrochloride
- 368/100
amiodarone hydrochloride
Amiodarone Hydrochloride
- 464/100
corvert
Ibutilide Fumarate
- 564/100
norpace
Disopyramide Phosphate
- 660/100
tikosyn
Dofetilide
- 7New
betapace
Sotalol Hydrochloride
- 8New
betapace af
Sotalol Hydrochloride
- 9New
nexterone
Amiodarone Hydrochloride
- 10New
sorine
Sotalol Hydrochloride
Frequently asked questions
What is the Antiarrhythmic drug class?
Antiarrhythmic is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 10 Antiarrhythmic products, each independently rated.
Are all Antiarrhythmic drugs the same?
No. Antiarrhythmic drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
What conditions do Antiarrhythmic drugs treat?
Per NIH RxClass drug-classification data, Antiarrhythmic drugs are used for conditions including atrial fibrillation, tachycardia, supraventricular, diabetic neuropathies, ventricular fibrillation, ventricular premature complexes, atrial flutter.
Which Antiarrhythmic drug is best-rated?
By our independent rating, propafenone hydrochloride currently ranks highest among Antiarrhythmic drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Antiarrhythmic class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Antiarrhythmic Medications - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.