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Best Antiarrhythmic for ventricular premature complexes

Top-rated pick: Mexiletine Hydrochloride — pharmaranks score 70/100, the highest of the 2 Antiarrhythmic drugs used for ventricular premature complexes, ranked by our independent FDA recall-safety score. Compare them with all treatments for ventricular premature complexes or the full Antiarrhythmic class. Not medical advice — always consult a professional.

Quick answer: Of the 2 antiarrhythmic drugs we rate for ventricular premature complexes, all are available as lower-cost generics, and most are capsule. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for ventricular premature complexes; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

How antiarrhythmic work

Antiarrhythmics steady an irregular heartbeat by controlling the flow of sodium, potassium, or calcium ions through heart-cell channels (or blunting adrenaline's effect), which slows or normalizes the heart's electrical signals so it beats in a more regular rhythm.

Source: Antiarrhythmic Medications - StatPearls - NCBI Bookshelf

Top antiarrhythmic for ventricular premature complexes: 1. Mexiletine Hydrochloride · 2. Norpace

Best-rated Antiarrhythmic for ventricular premature complexes, ranked by pharmaranks score
#DrugRatingPharmacy pays
170/100$8View →
264/100$25View →

Full ranking · 2 drugs

Frequently asked

What is the best antiarrhythmic for ventricular premature complexes?
By our independent recall-safety rating — not an efficacy measure — mexiletine hydrochloride ranks highest among Antiarrhythmic drugs used for ventricular premature complexes. Always consult a professional.
Which antiarrhythmic drugs treat ventricular premature complexes?
pharmaranks lists 2 Antiarrhythmic products used for ventricular premature complexes, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.