Best Antiarrhythmic for ventricular fibrillation
Top-rated pick: Mexiletine Hydrochloride — pharmaranks score 70/100, the highest of the 6 Antiarrhythmic drugs used for ventricular fibrillation, ranked by our independent FDA recall-safety score. Compare them with all treatments for ventricular fibrillation or the full Antiarrhythmic class. Not medical advice — always consult a professional.
Quick answer: Of the 6 antiarrhythmic drugs we rate for ventricular fibrillation, all are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for ventricular fibrillation; the right choice depends on your situation, so confirm it with your prescriber.
How antiarrhythmic work
Antiarrhythmics steady an irregular heartbeat by controlling the flow of sodium, potassium, or calcium ions through heart-cell channels (or blunting adrenaline's effect), which slows or normalizes the heart's electrical signals so it beats in a more regular rhythm.
Source: Antiarrhythmic Medications - StatPearls - NCBI Bookshelf
Other drug classes for ventricular fibrillation
Top antiarrhythmic for ventricular fibrillation: 1. Mexiletine Hydrochloride · 2. Amiodarone Hydrochloride · 3. Betapace
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Capsule | Generic | $8 | View → | |
| 2 | 68/100 | Prescription | Injectable | Generic | $4 | View → | |
| 3 | Not yet rated | Prescription | Tablet | Generic | $3 | View → | |
| 4 | Not yet rated | Prescription | Tablet | Generic | $3 | View → | |
| 5 | Not yet rated | Prescription | Injectable | Generic | $4 | View → | |
| 6 | Not yet rated | Prescription | Tablet | Generic | $3 | View → |
Full ranking · 6 drugs
mexiletine hydrochloride
PrescriptionFDA-sourced
Mexiletine Hydrochloride is an antiarrhythmic used to treat Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes.
Pharmacy pays
From ~$7.35/30· 3 forms Save up to 65% in classamiodarone hydrochloride
PrescriptionFDA-sourced
Amiodarone Hydrochloride is an antiarrhythmic used to treat Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$3.60/30· 4 forms Save up to 19% in classbetapace
Boxed warningPrescriptionFDA-sourced
Betapace (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsbetapace af
Boxed warningPrescriptionFDA-sourced
Betapace Af (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsnexterone
PrescriptionFDA-sourced
Nexterone (Amiodarone Hydrochloride) is an antiarrhythmic used to treat Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$3.60/30· 4 forms Save up to 19% in classsorine
Boxed warningPrescriptionFDA-sourced
Sorine (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsFrequently asked
- What is the best antiarrhythmic for ventricular fibrillation?
- By our independent recall-safety rating — not an efficacy measure — mexiletine hydrochloride ranks highest among Antiarrhythmic drugs used for ventricular fibrillation. Always consult a professional.
- Which antiarrhythmic drugs treat ventricular fibrillation?
- pharmaranks lists 6 Antiarrhythmic products used for ventricular fibrillation, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.