Best treatments for ventricular fibrillation
11 products may treat ventricular fibrillation, spanning FDA drug classes such as antiarrhythmic, amide local anesthetic, beta-adrenergic blocker. The current highest-rated option is mexiletine hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 11 drugs we list for ventricular fibrillation, 9 are available as lower-cost generics, spanning classes such as antiarrhythmic, amide local anesthetic, beta-adrenergic blocker. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for ventricular fibrillation — so confirm the right choice with your prescriber.
Top-rated picks for ventricular fibrillation: 1. Mexiletine Hydrochloride · 2. Amiodarone Hydrochloride · 3. Betapace
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Capsule | Antiarrhythmic | Generic | $8 | View → | |
| 2 | 68/100 | Prescription | Injectable | Antiarrhythmic | Generic | $4 | View → | |
| 3 | Not yet rated | Prescription | Tablet | Antiarrhythmic | Generic | $3 | View → | |
| 4 | Not yet rated | Prescription | Tablet | Antiarrhythmic | Generic | $3 | View → | |
| 5 | Not yet rated | Prescription | System | Amide Local Anesthetic | Generic | $0 | View → | |
| 6 | Not yet rated | Prescription | Injectable | beta-Adrenergic Blocker | No data | — | View → | |
| 7 | Not yet rated | Prescription | Injectable | beta-Adrenergic Blocker | No data | — | View → | |
| 8 | Not yet rated | Prescription | Patch | Amide Local Anesthetic | Generic | $0 | View → | |
| 9 | Not yet rated | Prescription | Injectable | Antiarrhythmic | Generic | $4 | View → | |
| 10 | Not yet rated | Prescription | Tablet | Antiarrhythmic | Generic | $3 | View → |
Narrow by drug class
Explore the class hubs: antiarrhythmic · amide local anesthetic · beta-adrenergic blocker
Full ranking · 11 treatments
mexiletine hydrochloride
PrescriptionFDA-sourced
Mexiletine Hydrochloride is an antiarrhythmic used to treat Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes.
Pharmacy pays
From ~$7.35/30· 3 forms Save up to 65% in classamiodarone hydrochloride
PrescriptionFDA-sourced
Amiodarone Hydrochloride is an antiarrhythmic used to treat Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$3.60/30· 4 forms Save up to 19% in classbetapace
Boxed warningPrescriptionFDA-sourced
Betapace (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsbetapace af
Boxed warningPrescriptionFDA-sourced
Betapace Af (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.
Pharmacy pays
From ~$2.08/30· 4 formsbondlido
PrescriptionFDA-sourced
Bondlido (Lidocaine) is an amide local anesthetic used to treat Burns, Esophageal Diseases, Mouth Diseases, Pain.
Pharmacy pays
From ~$0.07· 8 forms Save up to 74% in classbrevibloc
PrescriptionFDA-sourced
Brevibloc (Esmolol Hydrochloride) is a beta-adrenergic blocker used to treat Angina Pectoris, Heart Failure, Hypertension, Myocardial Infarction.
Price varies
Frequently asked
- What treats ventricular fibrillation?
- Our catalog lists 11 products that may treat ventricular fibrillation, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is mexiletine hydrochloride.
- What is the best-rated treatment for ventricular fibrillation?
- By our independent recall-safety rating — not an efficacy measure — mexiletine hydrochloride ranks highest among the products we list for ventricular fibrillation. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat ventricular fibrillation?
- Treatments for ventricular fibrillation span FDA drug classes including antiarrhythmic, amide local anesthetic, beta-adrenergic blocker. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.