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Best Antiarrhythmic for tachycardia, supraventricular

Top-rated pick: Propafenone Hydrochloride — pharmaranks score 72/100, the highest of the 6 Antiarrhythmic drugs used for tachycardia, supraventricular, ranked by our independent FDA recall-safety score. Compare them with all treatments for tachycardia, supraventricular or the full Antiarrhythmic class. Not medical advice — always consult a professional.

Quick answer: Of the 6 antiarrhythmic drugs we rate for tachycardia, supraventricular, all are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for tachycardia, supraventricular; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

How antiarrhythmic work

Antiarrhythmics steady an irregular heartbeat by controlling the flow of sodium, potassium, or calcium ions through heart-cell channels (or blunting adrenaline's effect), which slows or normalizes the heart's electrical signals so it beats in a more regular rhythm.

Source: Antiarrhythmic Medications - StatPearls - NCBI Bookshelf

Other drug classes for tachycardia, supraventricular

Top antiarrhythmic for tachycardia, supraventricular: 1. Propafenone Hydrochloride · 2. Amiodarone Hydrochloride · 3. Betapace

Best-rated Antiarrhythmic for tachycardia, supraventricular, ranked by pharmaranks score
#DrugRatingPharmacy pays
172/100$11View →
268/100$4View →
3Not yet rated$3View →
4Not yet rated$3View →
5Not yet rated$4View →
6Not yet rated$3View →

Full ranking · 6 drugs

#1 of 12 in Antiarrhythmic

propafenone hydrochloride

Boxed warning

PrescriptionFDA-sourced

72/100

Propafenone Hydrochloride is an antiarrhythmic used to treat Atrial Fibrillation, Supraventricular Tachycardia.

(4 data points)
antiarrhythmicatrial fibrillationtachycardia, supraventricular

Pharmacy pays

From ~$3.34/30· 6 forms Save up to 72% in class
View details →

amiodarone hydrochloride

PrescriptionFDA-sourced

68/100

Amiodarone Hydrochloride is an antiarrhythmic used to treat Supraventricular Tachycardia, Ventricular Fibrillation.

(33 data points)
antiarrhythmictachycardia, supraventricularventricular fibrillation

Pharmacy pays

From ~$3.60/30· 4 forms Save up to 19% in class
View details →

betapace

Boxed warning

PrescriptionFDA-sourced

New

Betapace (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.

antiarrhythmicatrial fibrillationatrial flutter

Pharmacy pays

From ~$2.08/30· 4 forms
View details →

betapace af

Boxed warning

PrescriptionFDA-sourced

New

Betapace Af (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.

antiarrhythmicatrial fibrillationatrial flutter

Pharmacy pays

From ~$2.08/30· 4 forms
View details →

nexterone

PrescriptionFDA-sourced

New

Nexterone (Amiodarone Hydrochloride) is an antiarrhythmic used to treat Supraventricular Tachycardia, Ventricular Fibrillation.

antiarrhythmictachycardia, supraventricularventricular fibrillation

Pharmacy pays

From ~$3.60/30· 4 forms Save up to 19% in class
View details →

sorine

Boxed warning

PrescriptionFDA-sourced

New

Sorine (Sotalol Hydrochloride) is an antiarrhythmic used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Ventricular Fibrillation.

antiarrhythmicatrial fibrillationatrial flutter

Pharmacy pays

From ~$2.08/30· 4 forms
View details →

Frequently asked

What is the best antiarrhythmic for tachycardia, supraventricular?
By our independent recall-safety rating — not an efficacy measure — propafenone hydrochloride ranks highest among Antiarrhythmic drugs used for tachycardia, supraventricular. Always consult a professional.
Which antiarrhythmic drugs treat tachycardia, supraventricular?
pharmaranks lists 6 Antiarrhythmic products used for tachycardia, supraventricular, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.