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Best beta-Adrenergic Blocker for atrial fibrillation

Top-rated pick: Atenolol — pharmaranks score 62/100, the highest of the 7 beta-Adrenergic Blocker drugs used for atrial fibrillation, ranked by our independent FDA recall-safety score. Compare them with all treatments for atrial fibrillation or the full beta-Adrenergic Blocker class. Not medical advice — always consult a professional.

Quick answer: Of the 7 beta-adrenergic blocker drugs we rate for atrial fibrillation, 6 are available as lower-cost generics, and most are tablet. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for atrial fibrillation; the right choice depends on your situation, so confirm it with your prescriber.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

How beta-adrenergic blocker work

Beta-blockers block adrenaline (epinephrine) and noradrenaline from acting on beta-adrenergic receptors, mainly in the heart. This slows the heart rate, reduces how forcefully the heart contracts, and lowers blood pressure, easing the workload on the heart.

Source: Beta Blockers — StatPearls, NCBI Bookshelf (NIH)

Top beta-adrenergic blocker for atrial fibrillation: 1. Atenolol · 2. Kapspargo Sprinkle · 3. Lopressor

Best-rated beta-Adrenergic Blocker for atrial fibrillation, ranked by pharmaranks score
#DrugRatingPharmacy pays
162/100$1View →
2Not yet rated$1View →
3Not yet rated$1View →
4Not yet rated$1View →
5Not yet ratedView →
6Not yet rated$1View →
7Not yet rated$1View →

Full ranking · 7 drugs

atenolol

PrescriptionFDA-sourced

62/100

Atenolol is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

(37 data points)
beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.67/30· 3 forms Save up to 23% in class
View details →

kapspargo sprinkle

PrescriptionFDA-sourced

New

Kapspargo Sprinkle (Metoprolol Succinate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

lopressor

PrescriptionFDA-sourced

New

Lopressor (Metoprolol Tartrate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

metoprolol succinate

PrescriptionFDA-sourced

New

Metoprolol Succinate is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

rapiblyk

PrescriptionFDA-sourced

New

Rapiblyk (Landiolol Hydrochloride) is a beta-adrenergic blocker used to treat Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia.

beta-adrenergic blockeratrial fibrillationatrial flutter

Price varies

View details →

tenormin

PrescriptionFDA-sourced

New

Tenormin (Atenolol) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.67/30· 3 forms Save up to 23% in class
View details →

toprol-xl

PrescriptionFDA-sourced

New

Toprol-XL (Metoprolol Succinate) is a beta-adrenergic blocker used to treat Angina Pectoris, Atrial Fibrillation, Atrial Flutter, Heart Failure.

beta-adrenergic blockerangina pectorisatrial fibrillation

Pharmacy pays

From ~$0.51/30· 6 forms
View details →

Frequently asked

What is the best beta-adrenergic blocker for atrial fibrillation?
By our independent recall-safety rating — not an efficacy measure — atenolol ranks highest among beta-Adrenergic Blocker drugs used for atrial fibrillation. Always consult a professional.
Which beta-adrenergic blocker drugs treat atrial fibrillation?
pharmaranks lists 7 beta-Adrenergic Blocker products used for atrial fibrillation, per NIH RxClass drug-classification data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.