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AMIODARONE HYDROCHLORIDE vs RYTHMOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. AMIODARONE HYDROCHLORIDE and RYTHMOL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

amiodarone hydrochloriderythmol

Rating

68/100
70/100

Pharmacy pays

~$3.68 /30
~$10.51 /30

Type

RX
RX

Active ingredient

AMIODARONE HYDROCHLORIDE
PROPAFENONE HYDROCHLORIDE

Manufacturer

Fresenius Kabi USA
Glaxosmithkline

Dosage forms

Injectable, Tablet
Tablet

Drug class

Antiarrhythmic
Antiarrhythmic

Boxed warning

None
None

Half-life

—
about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Supraventricular Tachycardia, Ventricular Fibrillation
Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Amiodarone Hydrochloride or Rythmol?

By our independent rating, Rythmol scores higher — 3.5 vs 3.4 out of 5 for Amiodarone Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Amiodarone Hydrochloride or Rythmol?

Amiodarone Hydrochloride costs pharmacies less to acquire — about $3.68 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Amiodarone Hydrochloride and Rythmol?

Amiodarone Hydrochloride contains Amiodarone Hydrochloride, while Rythmol contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.