NORPACE vs RYTHMOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. NORPACE and RYTHMOL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NORPACE	RYTHMOL
Rating	64/100	70/100
Pharmacy pays	~$25.31 /30	~$10.51 /30
Type	RX	RX
Active ingredient	DISOPYRAMIDE PHOSPHATE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Pfizer	Glaxosmithkline
Dosage forms	Capsule	Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	Boxed warning	None
Half-life	—	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Atrial Fibrillation, Atrial Flutter, Ventricular Premature Complexes	Atrial Fibrillation, Supraventricular Tachycardia

norpace rythmol

Rating

64/100

70/100

Pharmacy pays

~$25.31 /30

~$10.51 /30

Type

Active ingredient

DISOPYRAMIDE PHOSPHATE

PROPAFENONE HYDROCHLORIDE

Manufacturer

Pfizer

Glaxosmithkline

Dosage forms

Capsule

Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

—

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Atrial Fibrillation, Atrial Flutter, Ventricular Premature Complexes

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Norpace or Rythmol?

By our independent rating, Rythmol scores higher — 3.5 vs 3.2 out of 5 for Norpace. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Norpace or Rythmol?

Rythmol costs pharmacies less to acquire — about $10.51 vs $25.31 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Norpace and Rythmol?

Norpace contains Disopyramide Phosphate, while Rythmol contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.