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prilosec otc

Pharmaranks rates Prilosec OTC 3.5/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Prilosec OTC (Omeprazole Magnesium) is a proton pump inhibitor used to treat Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux, Heartburn.

Omeprazole Magnesium · by Astrazeneca

Available as a generic: Omeprazole Magnesium

70/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate
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Key facts

Active ingredient
Omeprazole Magnesium
Form
Tablet, delayed release
Strength
Omeprazole Magnesium EQ 20MG Base
Type
Over-the-counter (OTC)
Brand or generic
Brand-name
Manufacturer
Astrazeneca
Half-life
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults (how long it stays in your system)
FDA application
NDA021229

What is Prilosec OTC?

From the FDA label:Use treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

How to use

Directions for adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days it may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours 14-Day Course of Treatment swallow 1 tablet with a glass of water before eating in the morning take every day for 14 days do not take more than 1 tablet a day do not use for more than 14 days unless directed by your doctor swallow whole. Do not chew, crush, or suck tablets. Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.

Warnings

Important safety information

Allergy alert: • Do not use if you are allergic to omeprazole. • Omeprazole may cause severe skin reactions. Symptoms may include: • skin reddening • blisters • rash If an allergic reaction occurs, stop use and seek medical help right away.

Overdose — what happens if you take too much

In case of overdose, get medical help or contact a Poison Control Center right away.

U.S. Poison Control: call or text 1-800-222-1222 (free, 24/7). In an emergency call 911. From the FDA label; not medical advice.

How long does Omeprazole Magnesium stay in your body?

The elimination half-life of omeprazole magnesium is about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The half-life is longer in older adults (about 1 hour) and in people with chronic liver disease (nearly 3 hours); its metabolites have little or no activity, but because omeprazole irreversibly binds the stomach's acid pump, its acid-blocking effect lasts far longer than this short half-life would suggest.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: OMEPRAZOLE capsule, delayed release — DailyMed (FDA label), Clinical Pharmacology / Pharmacokinetics.

Drug class

How this class works, per Proton Pump Inhibitors (PPI) - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Prilosec OTC ranks — best-rated proton pump inhibitor for:

Dosage forms

Tablet, delayed release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

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Frequently asked questions

What does Prilosec OTC treat?
Prilosec OTC (Omeprazole Magnesium) may be used to treat duodenal ulcer, esophagitis, gastroesophageal reflux, heartburn, stomach ulcer, zollinger-ellison syndrome, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Prilosec OTC work?
Prilosec OTC is a proton pump inhibitor. Proton pump inhibitors block the H+/K+ ATPase 'proton pump' in the stomach's acid-making cells, the final step in producing stomach acid. By binding this pump, they sharply and lastingly cut acid output, easing heartburn and helping ulcers heal.
How is Prilosec OTC rated?
pharmaranks gives Prilosec OTC a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
Is there a coupon or discount for Prilosec OTC?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Prilosec OTC. To pay less, look for a store-brand version with the same active ingredient (Omeprazole Magnesium), which is typically cheaper, and compare unit prices. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Prilosec OTC?
Prilosec OTC is marketed by Astrazeneca. You can see Astrazeneca's full profile, rating, and other products on pharmaranks.
Is Prilosec OTC a brand-name or generic drug?
Prilosec OTC is a brand-name product with the active ingredient Omeprazole Magnesium. Lower-cost generic equivalents containing Omeprazole Magnesium are available — ask your pharmacist.
Is Prilosec OTC available over the counter?
Yes. Prilosec OTC is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
What forms does Prilosec OTC come in?
Prilosec OTC is currently marketed as tablet, delayed release, per the FDA's National Drug Code Directory.
What class of drug is Prilosec OTC?
Prilosec OTC is classified as proton pump inhibitor, per the FDA's Established Pharmacologic Class.
Is Prilosec OTC FDA-registered?
Prilosec OTC is on record with the U.S. FDA under application number NDA021229. You can verify this on its official FDA label.
Has Prilosec OTC been recalled by the FDA?
Prilosec OTC has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Prilosec OTC safe?
There's no single safe-or-not verdict. pharmaranks gives Prilosec OTC a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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