ESOMEPRAZOLE MAGNESIUM vs PRILOSEC OTC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Attribute	ESOMEPRAZOLE MAGNESIUM	PRILOSEC OTC
Rating	66/100	70/100
Pharmacy pays	—	—
Type	RX	OTC
Active ingredient	ESOMEPRAZOLE MAGNESIUM	OMEPRAZOLE MAGNESIUM
Manufacturer	Mylan	Astrazeneca
Dosage forms	Capsule, delayed release, Powder, extended release	Tablet, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

esomeprazole magnesium prilosec otc

Rating

66/100

70/100

Pharmacy pays

—

Type

OTC

Active ingredient

ESOMEPRAZOLE MAGNESIUM

OMEPRAZOLE MAGNESIUM

Manufacturer

Mylan

Astrazeneca

Dosage forms

Capsule, delayed release, Powder, extended release

Tablet, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Esomeprazole Magnesium or Prilosec OTC?

By our independent rating, Prilosec OTC scores higher — 3.5 vs 3.3 out of 5 for Esomeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Esomeprazole Magnesium and Prilosec OTC?

Esomeprazole Magnesium contains Esomeprazole Magnesium, while Prilosec OTC contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.