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benadryl preservative free

Benadryl Preservative Free (Diphenhydramine Hydrochloride) is a histamine-1 receptor antagonist used to treat Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness, Nausea.

Diphenhydramine Hydrochloride · by Mcneil Cons

Available as a generic: Diphenhydramine Hydrochloride

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Form
Injectable
Strength
Diphenhydramine Hydrochloride 50MG/ML **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
Manufacturer
Mcneil Cons
What the pharmacy pays
~$0.04 per ml — not your price
FDA application
NDA009486
Availability
Discontinued (per FDA)

Drug class

How this class works, per Antihistamines - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Benadryl Preservative Free ranks — best-rated histamine-1 receptor antagonist for:

Dosage forms

Injectable

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Benadryl Preservative Free treat?
Benadryl Preservative Free (Diphenhydramine Hydrochloride) may be used to treat anxiety disorders, sleep initiation and maintenance disorders, motion sickness, nausea, perennial allergic rhinitis, sneezing, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Benadryl Preservative Free work?
Benadryl Preservative Free is a histamine-1 receptor antagonist. H1 antihistamines work by blocking histamine, the chemical released during an allergic reaction, from attaching to H1 receptors. This prevents the sneezing, itching, runny nose, watery eyes, and hives that histamine would otherwise trigger.
How much does Benadryl Preservative Free cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.04 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Benadryl Preservative Free?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Benadryl Preservative Free. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Benadryl Preservative Free?
Benadryl Preservative Free is marketed by Mcneil Cons. You can see Mcneil Cons's full profile, rating, and other products on pharmaranks.
Is Benadryl Preservative Free a brand-name or generic drug?
Benadryl Preservative Free is a brand-name product with the active ingredient Diphenhydramine Hydrochloride. Lower-cost generic equivalents containing Diphenhydramine Hydrochloride are available — ask your pharmacist.
Is Benadryl Preservative Free available over the counter?
No. Benadryl Preservative Free is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Benadryl Preservative Free come in?
Benadryl Preservative Free is currently marketed as injectable, per the FDA's National Drug Code Directory.
What class of drug is Benadryl Preservative Free?
Benadryl Preservative Free is classified as histamine-1 receptor antagonist, per the FDA's Established Pharmacologic Class.
Is Benadryl Preservative Free FDA-registered?
Benadryl Preservative Free is on record with the U.S. FDA under application number NDA009486. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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