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BENADRYL PRESERVATIVE FREE vs CHILDREN'S ZYRTEC HIVES RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. BENADRYL PRESERVATIVE FREE and CHILDREN'S ZYRTEC HIVES RELIEF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

benadryl preservative freechildren's zyrtec hives relief

Rating

New
70/100

Pharmacy pays

$0.04 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

DIPHENHYDRAMINE HYDROCHLORIDE
CETIRIZINE HYDROCHLORIDE

Manufacturer

Mcneil Cons
Kenvue Brands

Dosage forms

Injectable
Tablet, chewable

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Half-life

—
about 8.3 hours (mean in healthy adults)

Treats

Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness
Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

Which is cheaper, Benadryl Preservative Free or Children's Zyrtec Hives Relief?

Benadryl Preservative Free costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Benadryl Preservative Free and Children's Zyrtec Hives Relief?

Benadryl Preservative Free contains Diphenhydramine Hydrochloride, while Children's Zyrtec Hives Relief contains Cetirizine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.