Antihistamines compared

Compare all 28 antihistamines side by side, used for conditions such as rhinitis, allergic, perennial, urticaria, conjunctivitis, allergic. Antihistamines are the Histamine-1 Receptor Antagonist class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is children's cetirizine hydrochloride allergy.

Top-rated histamine-1 receptor antagonist: 1. Children's Cetirizine Hydrochloride Allergy · 2. Children's Cetirizine Hydrochloride Hives Relief · 3. Children's Zyrtec Allergy

Histamine-1 Receptor Antagonist drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Children's Cetirizine Hydrochloride Allergy	Cetirizine Hydrochloride	Solution	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Children's Cetirizine Hydrochloride Hives Relief	Cetirizine Hydrochloride	Solution	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Children's Zyrtec Allergy	Cetirizine Hydrochloride	Solution	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Children's Zyrtec Hives	Cetirizine Hydrochloride	Solution	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Children's Zyrtec Hives Relief	Cetirizine Hydrochloride	Tablet	Prescription	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Zerviate	Cetirizine Hydrochloride	Solution	Prescription	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Zyrtec Allergy	Cetirizine Hydrochloride	Capsule	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Zyrtec Hives	Cetirizine Hydrochloride	Solution	Prescription	Rhinitis, Allergic, Perennial, Urticaria	70/100	$0
Cetirizine Hydrochloride	—	Solution	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	68/100	$0
Allegra Allergy	Fexofenadine Hydrochloride	Tablet	Over-the-counter	Rhinitis, Allergic, Perennial, Urticaria	Not yet rated	$7
Allegra Hives	Fexofenadine Hydrochloride	Tablet	Prescription	Rhinitis, Allergic, Perennial, Urticaria	Not yet rated	$7
Astepro Allergy	Azelastine Hydrochloride	Spray/Inhaler	Over-the-counter	Conjunctivitis, Allergic, Rhinitis, Allergic, Perennial	Not yet rated	$1

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best histamine-1 receptor antagonist by condition

for perennial allergic rhinitis for urticaria for allergic conjunctivitis for vasomotor rhinitis for seasonal allergic rhinitis

Full ranking · 28 drugs

Frequently asked questions

What is the Histamine-1 Receptor Antagonist drug class?

Histamine-1 Receptor Antagonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 28 Histamine-1 Receptor Antagonist products, each independently rated.

Are all Histamine-1 Receptor Antagonist drugs the same?

No. Histamine-1 Receptor Antagonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

Is "antihistamines" the same as the Histamine-1 Receptor Antagonist class?

Yes — "antihistamines" is the everyday name for the Histamine-1 Receptor Antagonist drug class. This page compares the 28 antihistamines pharmaranks rates, with our independent FDA recall-safety score for each.

What conditions do Histamine-1 Receptor Antagonist drugs treat?

Per NIH RxClass drug-classification data, Histamine-1 Receptor Antagonist drugs are used for conditions including rhinitis, allergic, perennial, urticaria, conjunctivitis, allergic, rhinitis, vasomotor, rhinitis, allergic, seasonal, angioedema.

Which Histamine-1 Receptor Antagonist drug is best-rated?

By our independent rating, children's cetirizine hydrochloride allergy currently ranks highest among Histamine-1 Receptor Antagonist drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Histamine-1 Receptor Antagonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Antihistamines - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.