zerviate

What is Zerviate?

From the FDA label:ZERVIATE ® is a sterile ophthalmic solution containing cetirizine, which is a histamine-1 (H1) receptor antagonist, for topical administration to the eyes. Cetirizine hydrochloride is a white, crystalline, water-soluble powder with a molecular weight of 461.8 and a molecular formula of C 21 H 25 ClN 2 O 3 •2HCl. The chemical structure is presented below: Chemical Name: ( RS )-2-[2-[4-[(4-Chlorophenyl) phenylmethyl] piperazin-1-yl] ethoxy] acetic acid, dihydrochloride Each mL of ZERVIATE ® contains an active ingredient [cetirizine 2.40 mg (equivalent to 2.85 mg of cetirizine hydrochloride)] and the following inactive ingredients: benzalkonium chloride 0.010% (preservative); glycerin; sodium phosphate, dibasic; edetate disodium; polyethylene glycol 400; polysorbate 80; hypromellose; hydrochloric acid/sodiumhydroxide (to adjust pH); and water for injection. ZERVIATE ® solution has a pH of approximately 7.0 and osmolality of approximately 300 mOsm/kg. Chemical Structure

How to use

Side effects

Warnings

Who should not take Zerviate

How long does Cetirizine Hydrochloride stay in your body?

The elimination half-life of cetirizine hydrochloride is about 8.3 hours (mean in healthy adults) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the parent drug's elimination half-life; cetirizine's only metabolite has negligible antihistaminic activity, so it does not prolong the effect. The half-life is shorter in young children (per the label, roughly 33-41% shorter in ages 2-5 and about 63% shorter in ages 6-23 months) and is expected to be longer in older adults and in people with kidney or liver impairment.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: CETIRIZINE HYDROCHLORIDE syrup (DailyMed).

Frequently asked questions

What does Zerviate treat?

Zerviate (Cetirizine Hydrochloride) may be used to treat perennial allergic rhinitis, urticaria, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Zerviate work?

Zerviate is a histamine-1 receptor antagonist. H1 antihistamines work by blocking histamine, the chemical released during an allergic reaction, from attaching to H1 receptors. This prevents the sneezing, itching, runny nose, watery eyes, and hives that histamine would otherwise trigger.

How is Zerviate rated?

pharmaranks gives Zerviate a composite score of 3.5 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Zerviate cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.06 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Zerviate?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Zerviate. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Zerviate?

Zerviate is marketed by Harrow Eye. You can see Harrow Eye's full profile, rating, and other products on pharmaranks.

Is Zerviate a brand-name or generic drug?

Zerviate is a brand-name product with the active ingredient Cetirizine Hydrochloride. Lower-cost generic equivalents containing Cetirizine Hydrochloride are available — ask your pharmacist.

Is Zerviate available over the counter?

No. Zerviate is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What class of drug is Zerviate?

Zerviate is classified as histamine-1 receptor antagonist, per the FDA's Established Pharmacologic Class.

Is Zerviate FDA-registered?

Zerviate is on record with the U.S. FDA under application number NDA208694. You can verify this on its official FDA label.

Has Zerviate been recalled by the FDA?

Zerviate has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Zerviate safe?

There's no single safe-or-not verdict. pharmaranks gives Zerviate a recall-safety score of 70/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

What are the side effects of Zerviate?

Zerviate's side effects are taken directly from its FDA label. From the label: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trial of a drug cannot be directly compared to rates in clinical trials of another drug and may not reflect the rates in practice. In seven clinical trials,… Both common and serious reactions are documented in full on this page. This is general reference from the FDA, not medical advice — always consult a professional.