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zyrtec

Zyrtec (Cetirizine Hydrochloride) is a histamine-1 receptor antagonist used to treat Perennial Allergic Rhinitis, Urticaria.

Cetirizine Hydrochloride

Available as a generic: Children's Cetirizine Hydrochloride Allergy

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 25, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
$0.06 /mL
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Key facts

Active ingredient
Cetirizine Hydrochloride
Form
Tablet, chewable
Type
Over-the-counter (OTC)
Brand or generic
Brand-name
Half-life
about 8.3 hours (mean in healthy adults) (how long it stays in your system)
What the pharmacy pays
~$0.06 per ml — not your price

What is Zyrtec?

From the FDA label:Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat

How to use

Directions may be taken with or without water chew or crush tablets completely before swallowing adults and children 6 years and over Chew and swallow 1 tablet (10 mg) once daily; do not take more than 1 tablet (10 mg) in 24 hours. A 5 mg product may be appropriate for less severe symptoms. adults 65 years and over ask a doctor children under 6 years of age ask a doctor consumers with liver or kidney disease ask a doctor

Warnings

Important safety information

Warnings Do not use if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine. Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose. Ask a doctor or pharmacist before use if you are taking tranquilizers or sedatives. When using this product drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery in rare cases, you may experience itching after stopping cetirizine. Consult your healthcare provider if this happens. Stop use and ask a doctor if an allergic reaction to this product occurs. Seek medical help right away. If pregnant or breast-feeding: if breast-feeding: not recommended if pregnant: ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

How long does Cetirizine Hydrochloride stay in your body?

The elimination half-life of cetirizine hydrochloride is about 8.3 hours (mean in healthy adults) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the parent drug's elimination half-life; cetirizine's only metabolite has negligible antihistaminic activity, so it does not prolong the effect. The half-life is shorter in young children (per the label, roughly 33-41% shorter in ages 2-5 and about 63% shorter in ages 6-23 months) and is expected to be longer in older adults and in people with kidney or liver impairment.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: CETIRIZINE HYDROCHLORIDE syrup (DailyMed).

Drug class

How this class works, per Antihistamines - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Zyrtec ranks — best-rated histamine-1 receptor antagonist for:

Dosage forms

Tablet, chewable

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Zyrtec treat?
Zyrtec (Cetirizine Hydrochloride) may be used to treat perennial allergic rhinitis, urticaria, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Zyrtec work?
Zyrtec is a histamine-1 receptor antagonist. H1 antihistamines work by blocking histamine, the chemical released during an allergic reaction, from attaching to H1 receptors. This prevents the sneezing, itching, runny nose, watery eyes, and hives that histamine would otherwise trigger.
How much does Zyrtec cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.06 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Zyrtec?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Zyrtec. To pay less, look for a store-brand version with the same active ingredient (Cetirizine Hydrochloride), which is typically cheaper, and compare unit prices. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Is Zyrtec a brand-name or generic drug?
Zyrtec is a brand-name product with the active ingredient Cetirizine Hydrochloride. Lower-cost generic equivalents containing Cetirizine Hydrochloride are available — ask your pharmacist.
Is Zyrtec available over the counter?
Yes. Zyrtec is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
What forms does Zyrtec come in?
Zyrtec is currently marketed as tablet, chewable, per the FDA's National Drug Code Directory.
What class of drug is Zyrtec?
Zyrtec is classified as histamine-1 receptor antagonist, per the FDA's Established Pharmacologic Class.
Is Zyrtec safe?
There's no single safe-or-not verdict, and we don't yet have a composite recall-safety score for Zyrtec. Review its FDA-label side effects and warnings below, and always consult a licensed professional.

Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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