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diphenhydramine hydrochloride

Diphenhydramine Hydrochloride is a histamine-1 receptor antagonist used to treat Anxiety Disorders, Sleep Initiation and Maintenance Disorders, Motion Sickness, Nausea.

Histamine-1 Receptor Antagonist · by Alra

Generic of Benadryl

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Form
Injectable, Solution, Capsule, Tablet
Strength
Diphenhydramine Hydrochloride 25MG · Diphenhydramine Hydrochloride 50MG
Type
Prescription (Rx)
Brand or generic
Generic
Manufacturer
Alra
What the pharmacy pays
~$0.04 per ml — not your price
FDA application
ANDA080519
Availability
Discontinued (per FDA)

Drug class

How this class works, per Antihistamines - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Diphenhydramine Hydrochloride ranks — best-rated histamine-1 receptor antagonist for:

Dosage forms

Injectable, Solution, Capsule and Tablet

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Diphenhydramine Hydrochloride treat?
Diphenhydramine Hydrochloride (Diphenhydramine Hydrochloride) may be used to treat anxiety disorders, sleep initiation and maintenance disorders, motion sickness, nausea, perennial allergic rhinitis, sneezing, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Diphenhydramine Hydrochloride work?
Diphenhydramine Hydrochloride is a histamine-1 receptor antagonist. H1 antihistamines work by blocking histamine, the chemical released during an allergic reaction, from attaching to H1 receptors. This prevents the sneezing, itching, runny nose, watery eyes, and hives that histamine would otherwise trigger.
How much does Diphenhydramine Hydrochloride cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.04 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Diphenhydramine Hydrochloride?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Diphenhydramine Hydrochloride. To pay less, Diphenhydramine Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Diphenhydramine Hydrochloride?
Diphenhydramine Hydrochloride is marketed by Alra. You can see Alra's full profile, rating, and other products on pharmaranks.
Is Diphenhydramine Hydrochloride a brand-name or generic drug?
Diphenhydramine Hydrochloride is a generic medication; its active ingredient is Diphenhydramine Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
Is Diphenhydramine Hydrochloride available over the counter?
No. Diphenhydramine Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Diphenhydramine Hydrochloride come in?
Diphenhydramine Hydrochloride is currently marketed as injectable, solution, capsule and tablet, per the FDA's National Drug Code Directory.
What class of drug is Diphenhydramine Hydrochloride?
Diphenhydramine Hydrochloride is classified as histamine-1 receptor antagonist, per the FDA's Established Pharmacologic Class.
Is Diphenhydramine Hydrochloride FDA-registered?
Diphenhydramine Hydrochloride is on record with the U.S. FDA under application number ANDA080519. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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