zonegran
Zonegran (Zonisamide) is an anti-epileptic agent used to treat Partial Epilepsies.
Zonisamide · by Advanz Pharma
Key facts
- Active ingredient
- Zonisamide
- Drug class
- Anti-Epileptic Agent
- Form
- Capsule
- Strength
- Zonisamide 100MG · Zonisamide 25MG · Zonisamide 50MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- partial epilepsies
- Manufacturer
- Advanz Pharma
- What the pharmacy pays
- ~$3.16 for 30 — not your price
- FDA application
- NDA020789
Drug class
How this class works, per Seizure Medications — StatPearls, NCBI Bookshelf (NIH).
May treat (source: NIH RxClass)
See how Zonegran ranks — best-rated anti-epileptic agent for:
Dosage forms
Capsule
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Zonegran treat?
- Zonegran (Zonisamide) may be used to treat partial epilepsies, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Zonegran work?
- Zonegran is a anti-epileptic agent. Anti-epileptic (anticonvulsant) drugs calm the abnormal, excessive electrical activity that triggers seizures. They do this by stabilizing overactive sodium or calcium channels in nerve cells, boosting the brain's natural calming chemical GABA, or dampening excitatory signals, which makes nerves less likely to fire uncontrollably.
- How much does Zonegran cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $3.16 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Mysoline — about $2.89 on the same basis.
- Is there a coupon or discount for Zonegran?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Zonegran. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Zonegran?
- Zonegran is marketed by Advanz Pharma. You can see Advanz Pharma's full profile, rating, and other products on pharmaranks.
- Is Zonegran a brand-name or generic drug?
- Zonegran is a brand-name product with the active ingredient Zonisamide.
- Is Zonegran available over the counter?
- No. Zonegran is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Zonegran come in?
- Zonegran is currently marketed as capsule, per the FDA's National Drug Code Directory.
- What class of drug is Zonegran?
- Zonegran is classified as anti-epileptic agent, per the FDA's Established Pharmacologic Class.
- Is Zonegran FDA-registered?
- Zonegran is on record with the U.S. FDA under application number NDA020789. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about ZONISAMIDE
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 10,919 reports naming ZONISAMIDE — the active ingredient in Zonegran, and the FDA flagged 77% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- seizure1,198 reports
- fatigue514 reports
- somnolence479 reports
- dizziness417 reports
- nausea401 reports
- headache378 reports
- fall374 reports
- vomiting327 reports
Read these as a signal, not a rate. A report does not mean ZONISAMIDE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 26, 2026.
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