MYSOLINE vs ZONEGRAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. MYSOLINE and ZONEGRAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	ZONEGRAN
Rating	70/100	New
Pharmacy pays	~$2.89 /30	~$3.16 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ZONISAMIDE
Manufacturer	Valeant Pharm Intl	Advanz Pharma
Dosage forms	Tablet	Capsule
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	Partial Epilepsies

mysoline zonegran

Rating

70/100

New

Pharmacy pays

~$2.89 /30

~$3.16 /30

Type

Active ingredient

PRIMIDONE

ZONISAMIDE

Manufacturer

Valeant Pharm Intl

Advanz Pharma

Dosage forms

Tablet

Capsule

Drug class

Anti-Epileptic Agent

Boxed warning

None

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Partial Epilepsies

Frequently asked questions

Which is cheaper, Mysoline or Zonegran?

Mysoline costs pharmacies less to acquire — about $2.89 vs $3.16 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Zonegran?

Mysoline contains Primidone, while Zonegran contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.