Anti-epileptic Agent drugs compared

Compare all 27 Anti-epileptic Agent drugs side by side, used for conditions such as epilepsies, partial, epilepsy, tonic-clonic, tremor. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is mysoline.

15 of 27 drugs in this class carry a pharmaranks safety score, ranging 66–74 out of 100 — computed from FDA recall records, not from reviews.

Rated against independent sources·Last updated September 9, 2026·How we rate

Top-rated anti-epileptic agent: 1. Mysoline · 2. Depakote · 3. Depakote ER

Anti-epileptic Agent drugs compared side by side, with pharmaranks' FDA recall-safety rating
Drug	Generic	Form	Status	Used for	Safety ratingFDA recall-based	Pharmacy pays
Mysoline	Primidone	Tablet	Prescription	Epilepsies, Partial, Epilepsy, Tonic-Clonic	74/100	$3
Depakote	Divalproex Sodium	Tablet	Prescription	Bipolar Disorder, Epilepsy	72/100	$6
Depakote ER	Divalproex Sodium	Tablet	Prescription	Bipolar Disorder, Epilepsy	72/100	$6
Felbamate	—	Suspension	Prescription	Seizures, Epilepsy, Complex Partial	72/100	$30
Fosphenytoin Sodium	—	Injectable	Prescription	Seizures, Status Epilepticus	72/100	—
Lamictal	Lamotrigine	Tablet	Prescription	Bipolar Disorder, Epilepsies, Partial	72/100	$4
Lamictal Cd	Lamotrigine	Tablet	Prescription	Bipolar Disorder, Epilepsies, Partial	72/100	$4
Lamictal ODT	Lamotrigine	Tablet	Prescription	Bipolar Disorder, Epilepsies, Partial	72/100	$4
Oxtellar XR	Oxcarbazepine	Tablet	Prescription	Epilepsies, Partial	72/100	$5
Valproate Sodium	—	Injectable	Prescription	—	72/100	—
Zonisade	Zonisamide	Suspension	Prescription	Epilepsies, Partial	72/100	$3
Primidone	—	Tablet	Prescription	Epilepsies, Partial, Epilepsy, Tonic-Clonic	70/100	$3

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best anti-epileptic agent by condition

for partial epilepsies for tonic-clonic epilepsy for tremor for bipolar disorder for epilepsy for absence epilepsy

Full ranking · 27 drugs

Frequently asked questions

What is the Anti-epileptic Agent drug class?

Anti-epileptic Agent is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 27 Anti-epileptic Agent products, each independently rated.

Are all Anti-epileptic Agent drugs the same?

No. Anti-epileptic Agent drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Anti-epileptic Agent drugs treat?

Per NIH RxClass drug-classification data, Anti-epileptic Agent drugs are used for conditions including epilepsies, partial, epilepsy, tonic-clonic, tremor, bipolar disorder, epilepsy, epilepsy, absence.

Which Anti-epileptic Agent drug is best-rated?

By our independent rating, mysoline currently ranks highest among Anti-epileptic Agent drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Anti-epileptic Agent class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Seizure Medications — StatPearls, NCBI Bookshelf (NIH). Ratings are pharmaranks’ independent FDA recall-safety analysis.