
periactin
Pharmaranks rates Periactin 3.6/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Periactin (Cyproheptadine Hydrochloride) is a medication used to treat Blepharospasm, Cluster Headache, Nelson Syndrome, Pruritus.
Cyproheptadine Hydrochloride · by Merck
Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →
Key facts
- Active ingredient
- Cyproheptadine Hydrochloride
- Form
- Syrup, Tablet
- Strength
- Cyproheptadine Hydrochloride 4MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- blepharospasm, cluster headache, nelson syndrome
- Manufacturer
- Merck
- What the pharmacy pays
- ~$0.07 per ml — not your price
- FDA application
- NDA012649
- Availability
- Discontinued (per FDA)
May treat (source: NIH RxClass)
Dosage forms
Syrup and Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Periactin treat?
- Periactin (Cyproheptadine Hydrochloride) may be used to treat blepharospasm, cluster headache, nelson syndrome, pruritus, perennial allergic rhinitis, schizophrenia, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How is Periactin rated?
- pharmaranks gives Periactin a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
- How much does Periactin cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.07 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Periactin?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Periactin. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Periactin?
- Periactin is marketed by Merck. You can see Merck's full profile, rating, and other products on pharmaranks.
- Is Periactin a brand-name or generic drug?
- Periactin is a brand-name product with the active ingredient Cyproheptadine Hydrochloride.
- Is Periactin available over the counter?
- No. Periactin is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Periactin come in?
- Periactin is currently marketed as syrup and tablet, per the FDA's National Drug Code Directory.
- Is Periactin FDA-registered?
- Periactin is on record with the U.S. FDA under application number NDA012649. You can verify this on its official FDA label.
- Has Periactin been recalled by the FDA?
- Periactin has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
- Is Periactin safe?
- There's no single safe-or-not verdict. pharmaranks gives Periactin a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about CYPROHEPTADINE HYDROCHLORIDE
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 1,223 reports naming CYPROHEPTADINE HYDROCHLORIDE — the active ingredient in Periactin, and the FDA flagged 67% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- vomiting96 reports
- diarrhoea88 reports
- fatigue88 reports
- pneumonia85 reports
- rash84 reports
- headache83 reports
- pruritus73 reports
- anxiety70 reports
Read these as a signal, not a rate. A report does not mean CYPROHEPTADINE HYDROCHLORIDE caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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periactin
72/100