ARISTADA vs PERIACTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. ARISTADA and PERIACTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ARISTADA	PERIACTIN
Rating	72/100	72/100
Pharmacy pays	—	$0.07 /mL
Type	RX	RX
Active ingredient	ARIPIPRAZOLE LAUROXIL	CYPROHEPTADINE HYDROCHLORIDE
Manufacturer	Alkermes Inc	Merck
Dosage forms	Injectable	Syrup, Tablet
Drug class	Atypical Antipsychotic	—
Boxed warning	Boxed warning	None
Half-life	about 75 hours (mean elimination half-life of the parent drug in typical adults)	—
Treats	Schizophrenia	Blepharospasm, Cluster Headache, Nelson Syndrome

aristada periactin

Rating

72/100

Pharmacy pays

—

$0.07 /mL

Type

Active ingredient

ARIPIPRAZOLE LAUROXIL

CYPROHEPTADINE HYDROCHLORIDE

Manufacturer

Alkermes Inc

Merck

Dosage forms

Injectable

Syrup, Tablet

Drug class

Atypical Antipsychotic

—

Boxed warning

None

Half-life

about 75 hours (mean elimination half-life of the parent drug in typical adults)

—

Treats

Schizophrenia

Blepharospasm, Cluster Headache, Nelson Syndrome

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Frequently asked questions

Which is better-rated, Aristada or Periactin?

Aristada and Periactin are tied at 3.6 out of 5 by our independent rating.

What is the difference between Aristada and Periactin?

Aristada contains Aripiprazole Lauroxil, while Periactin contains Cyproheptadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.