BOTOX vs PERIACTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. BOTOX and PERIACTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BOTOX	PERIACTIN
Rating	72/100	72/100
Pharmacy pays	—	$0.07 /mL
Type	RX	RX
Active ingredient	OnabotulinumtoxinA	CYPROHEPTADINE HYDROCHLORIDE
Manufacturer	Allergan	Merck
Dosage forms	Injectable	Syrup, Tablet
Drug class	—	—
Boxed warning	Boxed warning	None
Treats	Blepharospasm, Dystonia, Fissure in Ano	Blepharospasm, Cluster Headache, Nelson Syndrome

botox periactin

Rating

72/100

Pharmacy pays

—

$0.07 /mL

Type

Active ingredient

OnabotulinumtoxinA

CYPROHEPTADINE HYDROCHLORIDE

Manufacturer

Allergan

Merck

Dosage forms

Injectable

Syrup, Tablet

Drug class

—

Boxed warning

None

Treats

Blepharospasm, Dystonia, Fissure in Ano

Blepharospasm, Cluster Headache, Nelson Syndrome

Get periactin

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Frequently asked questions

Which is better-rated, Botox or Periactin?

Botox and Periactin are tied at 3.6 out of 5 by our independent rating.

What is the difference between Botox and Periactin?

Botox contains Onabotulinumtoxina, while Periactin contains Cyproheptadine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.