indomethacin

How long does Indomethacin stay in your body?

The elimination half-life of indomethacin is about 4.5 hours — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the parent drug's mean elimination half-life; at ~4.5 hours most of a dose clears from the blood in roughly a day (about 5 half-lives). Indomethacin undergoes appreciable enterohepatic circulation (it is reabsorbed from the gut), which can prolong how long it lingers. It is broken down to desmethyl, desbenzoyl, and desmethyldesbenzoyl metabolites; the label does not describe these as active or longer-lasting than the parent. The label reports no half-life data in kidney or liver impairment because indomethacin's pharmacokinetics were not studied in those patients, though clearance may be slower when organ function is reduced.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: INDOMETHACIN capsule — FDA label (DailyMed), Clinical Pharmacology: Pharmacokinetics.

Frequently asked questions

What does Indomethacin treat?

Indomethacin (Indomethacin) may be used to treat rheumatoid arthritis, bursitis, patent ductus arteriosus, inflammation, osteoarthritis, pain, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Indomethacin work?

Indomethacin is a nonsteroidal anti-inflammatory drug. NSAIDs block cyclooxygenase (COX) enzymes that your body uses to make prostaglandins, the chemicals behind pain, swelling, and fever. Lowering prostaglandins eases pain and inflammation and brings down a high temperature.

How is Indomethacin rated?

pharmaranks gives Indomethacin a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Indomethacin cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $4.06 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Indomethacin?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Indomethacin. To pay less, Indomethacin is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Indomethacin?

Indomethacin is marketed by Rising. You can see Rising's full profile, rating, and other products on pharmaranks.

Is Indomethacin a brand-name or generic drug?

Indomethacin is a generic medication; its active ingredient is Indomethacin. Generics contain the same active ingredient as the brand-name original and are usually lower cost.

Is Indomethacin available over the counter?

No. Indomethacin is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Indomethacin come in?

Indomethacin is currently marketed as capsule, capsule, extended release and suppository, per the FDA's National Drug Code Directory.

What class of drug is Indomethacin?

Indomethacin is classified as nonsteroidal anti-inflammatory drug, per the FDA's Established Pharmacologic Class.

Is Indomethacin FDA-registered?

Indomethacin is on record with the U.S. FDA under application number ANDA070624. You can verify this on its official FDA label.

Has Indomethacin been recalled by the FDA?

Indomethacin has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Indomethacin safe?

There's no single safe-or-not verdict. pharmaranks gives Indomethacin a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.