INDOMETHACIN vs NAPROXEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. INDOMETHACIN and NAPROXEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOMETHACIN	NAPROXEN
Rating	72/100	72/100
Pharmacy pays	~$4.06 /30	$0.06 /mL
Type	RX	RX
Active ingredient	INDOMETHACIN	NAPROXEN
Manufacturer	Rising	Hikma
Dosage forms	Capsule, Capsule, extended release, Suppository	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 4.5 hours	about 12 to 17 hours
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

indomethacin naproxen

Rating

72/100

Pharmacy pays

~$4.06 /30

$0.06 /mL

Type

Active ingredient

INDOMETHACIN

NAPROXEN

Manufacturer

Rising

Hikma

Dosage forms

Capsule, Capsule, extended release, Suppository

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 4.5 hours

about 12 to 17 hours

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Frequently asked questions

Which is better-rated, Indomethacin or Naproxen?

Indomethacin and Naproxen are tied at 3.6 out of 5 by our independent rating.

What is the difference between Indomethacin and Naproxen?

Indomethacin contains Indomethacin, while Naproxen contains Naproxen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.