glynase

How long does Glyburide stay in your body?

The elimination half-life of glyburide is about 10 hours (terminal/elimination half-life) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. The label says the fall in glyburide serum levels in healthy people is biphasic — this 10 hours is the terminal (elimination) phase, not the earlier distribution phase. Glyburide is not a prodrug. It has two metabolites (the 4-trans-hydroxy and 3-cis-hydroxy derivatives), but the label states they are only weakly active (about 1/400th and 1/40th as active as glyburide in rabbits) and "probably contribute no significant hypoglycemic action in humans," so there is no active metabolite that outlasts the parent in a clinically meaningful way. The label gives no separate half-life numbers for older adults, kidney impairment, or liver impairment — it does warn that impaired kidney or liver function can raise glyburide levels and that liver impairment reduces gluconeogenesis, both raising hypoglycemia risk, and that older adults are prone to kidney insufficiency and are particularly susceptible to hypoglycemia. Glyburide is unusual among sulfonylureas in being cleared by two routes, roughly 50% in bile and 50% in urine, as metabolites. This is a pharmacokinetic figure, not a drug-test detection window and not dosing guidance.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Glyburide tablets, USP — FDA label (DailyMed), CLINICAL PHARMACOLOGY / Pharmacokinetics.

Frequently asked questions

What does Glynase treat?

Glynase (Glyburide) may be used to treat type 2 diabetes mellitus, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How is Glynase rated?

pharmaranks gives Glynase a composite score of 3.2 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.

How much does Glynase cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $1.97 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins. Pharmacies pay less for a same-class option, Glimepiride — about $1.00 on the same basis.

Is there a coupon or discount for Glynase?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Glynase. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Glynase?

Glynase is marketed by Pfizer. You can see Pfizer's full profile, rating, and other products on pharmaranks.

Is Glynase a brand-name or generic drug?

Glynase is a brand-name product with the active ingredient Glyburide. Lower-cost generic equivalents containing Glyburide are available — ask your pharmacist.

Is Glynase available over the counter?

No. Glynase is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Glynase come in?

Glynase is currently marketed as tablet, per the FDA's National Drug Code Directory.

What class of drug is Glynase?

Glynase is classified as sulfonylurea, per the FDA's Established Pharmacologic Class.

Is Glynase FDA-registered?

Glynase is on record with the U.S. FDA under application number NDA020051. You can verify this on its official FDA label.

Has Glynase been recalled by the FDA?

Glynase has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.

Is Glynase safe?

There's no single safe-or-not verdict. pharmaranks gives Glynase a recall-safety score of 64/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.