GLIMEPIRIDE vs GLYNASE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. GLIMEPIRIDE and GLYNASE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GLIMEPIRIDE	GLYNASE
Rating	New	64/100
Pharmacy pays	~$1.00 /30	~$1.97 /30
Type	RX	RX
Active ingredient	GLIMEPIRIDE	GLYBURIDE
Manufacturer	Dr Reddys	Pfizer
Dosage forms	Tablet	Tablet
Drug class	Sulfonylurea	Sulfonylurea
Boxed warning	None	None
Half-life	about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)	about 10 hours (terminal/elimination half-life)
Treats	Type 2 Diabetes Mellitus	Type 2 Diabetes Mellitus

glimepiride glynase

Rating

New

64/100

Pharmacy pays

~$1.00 /30

~$1.97 /30

Type

Active ingredient

GLIMEPIRIDE

GLYBURIDE

Manufacturer

Dr Reddys

Pfizer

Dosage forms

Tablet

Drug class

Sulfonylurea

Boxed warning

None

Half-life

about 5 hours (label mean 5.3 hours in adults, ± 4.1 hours — variation between people is wide)

about 10 hours (terminal/elimination half-life)

Treats

Type 2 Diabetes Mellitus

Get glynasehigher-rated option

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Frequently asked questions

Which is cheaper, Glimepiride or Glynase?

Glimepiride costs pharmacies less to acquire — about $1.00 vs $1.97 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Glimepiride and Glynase?

Glimepiride contains Glimepiride, while Glynase contains Glyburide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.