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Sulfonylurea drugs compared

Compare all 5 Sulfonylurea drugs side by side, used for conditions such as diabetes mellitus, type 2. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is diabeta.

Top-rated sulfonylurea: 1. Diabeta · 2. Glyburide · 3. Glipizide

Sulfonylurea drugs compared side by side, with pharmaranks' FDA recall-safety rating
DrugGenericSafety ratingFDA recall-based
DiabetaGlyburide70/100
Glyburide—70/100
Glipizide—66/100
Glucotrol XLGlipizide64/100
Glimepiride—Not yet rated

The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.

Best sulfonylurea by condition

for type 2 diabetes mellitus

Full ranking · 5 drugs

  1. 1

    diabeta

    Glyburide

    70/100
  2. 2

    glyburide

    Glyburide

    70/100
  3. 3

    glipizide

    Glipizide

    66/100
  4. 4

    glucotrol xl

    Glipizide

    64/100
  5. 5

    glimepiride

    Glimepiride

    New

Frequently asked questions

What is the Sulfonylurea drug class?

Sulfonylurea is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 5 Sulfonylurea products, each independently rated.

Are all Sulfonylurea drugs the same?

No. Sulfonylurea drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.

What conditions do Sulfonylurea drugs treat?

Per NIH RxClass drug-classification data, Sulfonylurea drugs are used for conditions including diabetes mellitus, type 2.

Which Sulfonylurea drug is best-rated?

By our independent rating, diabeta currently ranks highest among Sulfonylurea drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.

Sources: the Sulfonylurea class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.