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GLUCOTROL XL vs GLYNASE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. GLUCOTROL XL and GLYNASE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

64/100
64/100

Pharmacy pays

~$1.41 /30
~$1.97 /30

Type

RX
RX

Active ingredient

GLIPIZIDE
GLYBURIDE

Manufacturer

Dosage forms

Tablet, extended release
Tablet

Drug class

Sulfonylurea
Sulfonylurea

Boxed warning

None
None

Half-life

about 2 to 4 hours
about 10 hours (terminal/elimination half-life)

Treats

Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus

Get glucotrol xlhigher-rated option

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Frequently asked questions

Which is better-rated, Glucotrol XL or Glynase?

Glucotrol XL and Glynase are tied at 3.2 out of 5 by our independent rating.

Which is cheaper, Glucotrol XL or Glynase?

Glucotrol XL costs pharmacies less to acquire — about $1.41 vs $1.97 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Glucotrol XL and Glynase?

Glucotrol XL contains Glipizide, while Glynase contains Glyburide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.