evzio (autoinjector)

How long does Naloxone Hydrochloride stay in your body?

The elimination half-life of naloxone hydrochloride is 30 to 81 minutes (mean 64 ± 12 minutes) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. This is the serum elimination half-life in adults with normal organ function; naloxone is metabolized in the liver by glucuronide conjugation (major metabolite naloxone-3-glucuronide, which is inactive) and excreted in urine. The half-life is much longer in neonates (mean 3.1 ± 0.5 hours). Because naloxone's half-life is short — often shorter than that of the opioids it reverses — its effects can wear off before the opioid does, so repeat dosing may be needed. Half-life is a pharmacokinetic elimination measure, not a drug-test detection window.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: NALOXONE HYDROCHLORIDE injection — DailyMed FDA label.

Frequently asked questions

What does Evzio (Autoinjector) treat?

Evzio (Autoinjector) (Naloxone Hydrochloride) may be used to treat opioid-related disorders, respiration disorders, septic shock, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.

How does Evzio (Autoinjector) work?

Evzio (Autoinjector) is a opioid antagonist. Opioid antagonists attach to the same brain and body receptors that opioids use, but without switching them on. By occupying those receptors, they block opioids from binding and can rapidly reverse an overdose or curb opioid cravings.

How much does Evzio (Autoinjector) cost?

Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $4.41 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.

Is there a coupon or discount for Evzio (Autoinjector)?

pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Evzio (Autoinjector). To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.

Who makes Evzio (Autoinjector)?

Evzio (Autoinjector) is marketed by Kaleo Inc. You can see Kaleo Inc's full profile, rating, and other products on pharmaranks.

Is Evzio (Autoinjector) a brand-name or generic drug?

Evzio (Autoinjector) is a brand-name product with the active ingredient Naloxone Hydrochloride. Lower-cost generic equivalents containing Naloxone Hydrochloride are available — ask your pharmacist.

Is Evzio (Autoinjector) available over the counter?

No. Evzio (Autoinjector) is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.

What forms does Evzio (Autoinjector) come in?

Evzio (Autoinjector) is currently marketed as solution, per the FDA's National Drug Code Directory.

What class of drug is Evzio (Autoinjector)?

Evzio (Autoinjector) is classified as opioid antagonist, per the FDA's Established Pharmacologic Class.

Is Evzio (Autoinjector) FDA-registered?

Evzio (Autoinjector) is on record with the U.S. FDA under application number NDA209862. You can verify this on its official FDA label.