EVZIO (AUTOINJECTOR) vs NARCAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	EVZIO (AUTOINJECTOR)	NARCAN
Rating	New	New
Pharmacy pays	$4.41 /mL	$4.41 /mL
Type	RX	OTC
Active ingredient	NALOXONE HYDROCHLORIDE	NALOXONE HYDROCHLORIDE
Manufacturer	Kaleo Inc	Emergent
Dosage forms	Solution	Spray/Inhaler
Drug class	Opioid Antagonist	Opioid Antagonist
Boxed warning	None	None
Half-life	30 to 81 minutes (mean 64 ± 12 minutes)	30 to 81 minutes (mean 64 ± 12 minutes)
Treats	Opioid-Related Disorders, Respiration Disorders, Septic Shock	Opioid-Related Disorders, Respiration Disorders, Septic Shock

evzio (autoinjector)narcan

Rating

New

Pharmacy pays

$4.41 /mL

Type

OTC

Active ingredient

NALOXONE HYDROCHLORIDE

Manufacturer

Kaleo Inc

Emergent

Dosage forms

Solution

Spray/Inhaler

Drug class

Opioid Antagonist

Boxed warning

None

Half-life

30 to 81 minutes (mean 64 ± 12 minutes)

Treats

Opioid-Related Disorders, Respiration Disorders, Septic Shock

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Where to buy

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Frequently asked questions

Which is cheaper, Evzio (Autoinjector) or Narcan?

Pharmacies pay about the same to acquire either one — roughly $4.41 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Evzio (Autoinjector) and Narcan?

Both Evzio (Autoinjector) and Narcan share the active ingredient Naloxone Hydrochloride, but Evzio (Autoinjector) is sold as RX and Narcan as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.