EVZIO (AUTOINJECTOR) vs OPVEE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. EVZIO (AUTOINJECTOR) and OPVEE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EVZIO (AUTOINJECTOR)	OPVEE
Rating	New	New
Pharmacy pays	$4.41 /mL	—
Type	RX	RX
Active ingredient	NALOXONE HYDROCHLORIDE	NALMEFENE HYDROCHLORIDE
Manufacturer	Kaleo Inc	Indivior
Dosage forms	Solution	Spray/Inhaler
Drug class	Opioid Antagonist	Opioid Antagonist
Boxed warning	None	None
Half-life	30 to 81 minutes (mean 64 ± 12 minutes)	—
Treats	Opioid-Related Disorders, Respiration Disorders, Septic Shock	Opioid-Related Disorders, Respiration Disorders, Drug Overdose

evzio (autoinjector)opvee

Rating

New

Pharmacy pays

$4.41 /mL

—

Type

Active ingredient

NALOXONE HYDROCHLORIDE

NALMEFENE HYDROCHLORIDE

Manufacturer

Kaleo Inc

Indivior

Dosage forms

Solution

Spray/Inhaler

Drug class

Opioid Antagonist

Boxed warning

None

Half-life

30 to 81 minutes (mean 64 ± 12 minutes)

—

Treats

Opioid-Related Disorders, Respiration Disorders, Septic Shock

Opioid-Related Disorders, Respiration Disorders, Drug Overdose

Frequently asked questions

What is the difference between Evzio (Autoinjector) and Opvee?

Evzio (Autoinjector) contains Naloxone Hydrochloride, while Opvee contains Nalmefene Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.