Best treatments for opioid-related disorders
9 products may treat opioid-related disorders, spanning FDA drug classes such as opioid agonist, opioid antagonist. The current highest-rated option is methadone hydrochloride. Ranked below by our independent recall-safety rating (rated where FDA data exists) — not medical advice; always consult a professional.
Quick answer: Of the 9 drugs we list for opioid-related disorders, 7 are available as lower-cost generics, spanning classes such as opioid agonist, opioid antagonist. They’re ranked by each drug’s FDA recall-safety record — not clinical effectiveness for opioid-related disorders — so confirm the right choice with your prescriber.
Top-rated picks for opioid-related disorders: 1. Methadone Hydrochloride · 2. Naloxone · 3. Methadose
| # | Drug | Rating | Type | Form | Class | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|---|
| 1 | 72/100 | Prescription | Injectable | Opioid Agonist | Generic | $0 | View → | |
| 2 | 72/100 | Prescription | Injectable | Opioid Antagonist | Generic | $4 | View → | |
| 3 | 70/100 | Prescription | Concentrate | Opioid Agonist | Generic | $0 | View → | |
| 4 | 70/100 | Prescription | Kit | Opioid Antagonist | Generic | $36 | View → | |
| 5 | Not yet rated | Over-the-counter | Spray/Inhaler | Opioid Antagonist | Generic | $4 | View → | |
| 6 | Not yet rated | Prescription | Spray/Inhaler | Opioid Antagonist | No data | — | View → | |
| 7 | Not yet rated | Prescription | Spray/Inhaler | Opioid Antagonist | Generic | $4 | View → | |
| 8 | Not yet rated | Prescription | Injectable | Opioid Antagonist | Generic | $4 | View → | |
| 9 | Not yet rated | Prescription | Injectable | Opioid Antagonist | No data | — | View → |
Narrow by drug class
Explore the class hubs: opioid antagonist · opioid agonist
Full ranking · 9 treatments
methadone hydrochloride
Boxed warningPrescriptionFDA-sourced
Methadone Hydrochloride is an opioid agonist used to treat Opioid-Related Disorders, Intractable Pain.
Pharmacy pays
From ~$0.06· 5 forms Save up to 70% in classnaloxone
PrescriptionFDA-sourced
Naloxone (Naloxone Hydrochloride) is an opioid antagonist used to treat Opioid-Related Disorders, Respiration Disorders, Septic Shock.
Pharmacy pays
From ~$4.23· 4 formsmethadose
Boxed warningPrescriptionFDA-sourced
Methadose (Methadone Hydrochloride) is an opioid agonist used to treat Opioid-Related Disorders, Intractable Pain.
Pharmacy pays
From ~$0.06· 5 forms Save up to 70% in classvivitrol
PrescriptionFDA-sourced
Vivitrol (Naltrexone) is an opioid antagonist used to treat Alcoholism, Opioid-Related Disorders, Drug Overdose.
Pharmacy pays
~$36.35 /30
narcan
Over-the-counterFDA-sourced
Narcan (Naloxone Hydrochloride) is an opioid antagonist used to treat Opioid-Related Disorders, Respiration Disorders, Septic Shock.
Pharmacy pays
From ~$4.23· 4 formsopvee
PrescriptionFDA-sourced
Opvee (Nalmefene Hydrochloride) is an opioid antagonist used to treat Opioid-Related Disorders, Respiration Disorders, Drug Overdose.
Price varies
Frequently asked
- What treats opioid-related disorders?
- Our catalog lists 9 products that may treat opioid-related disorders, based on NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. They're rated where FDA recall-safety data exists; the current top-rated option is methadone hydrochloride.
- What is the best-rated treatment for opioid-related disorders?
- By our independent recall-safety rating — not an efficacy measure — methadone hydrochloride ranks highest among the products we list for opioid-related disorders. Always consult a professional.
- How are these treatments ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
- What types of drugs treat opioid-related disorders?
- Treatments for opioid-related disorders span FDA drug classes including opioid agonist, opioid antagonist. Compare every option side by side, ranked by independent rating, above.
Treatment associations are derived from NIH RxClass (MED-RT “may treat”) drug-classification data — not the verbatim FDA label. This is general reference, not medical advice — always consult a licensed professional.