Opioid Antagonist drugs compared
Compare all 9 Opioid Antagonist drugs side by side, used for conditions such as opioid-related disorders, respiration disorders, shock, septic. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is naloxone.
Top-rated opioid antagonist: 1. Naloxone · 2. Vivitrol · 3. Narcan
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Naloxone | Naloxone Hydrochloride | Injectable | Prescription | Opioid-Related Disorders, Respiration Disorders | 72/100 | $4 |
| Vivitrol | Naltrexone | Kit | Prescription | Alcoholism, Opioid-Related Disorders | 70/100 | $36 |
| Narcan | Naloxone Hydrochloride | Spray/Inhaler | Over-the-counter | Opioid-Related Disorders, Respiration Disorders | Not yet rated | $4 |
| Opvee | Nalmefene Hydrochloride | Spray/Inhaler | Prescription | Opioid-Related Disorders, Respiration Disorders | Not yet rated | — |
| Relistor | Methylnaltrexone Bromide | Injectable | Prescription | Constipation | Not yet rated | — |
| Rezenopy | Naloxone Hydrochloride | Spray/Inhaler | Prescription | Opioid-Related Disorders, Respiration Disorders | Not yet rated | $4 |
| Symproic | Naldemedine Tosylate | Tablet | Prescription | Constipation | Not yet rated | — |
| Zimhi | Naloxone Hydrochloride | Injectable | Prescription | Opioid-Related Disorders, Respiration Disorders | Not yet rated | $4 |
| Zurnai (Autoinjector) | Nalmefene Hydrochloride | Injectable | Prescription | Opioid-Related Disorders, Respiration Disorders | Not yet rated | — |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best opioid antagonist by condition
Full ranking · 9 drugs
- 172/100
naloxone
Naloxone Hydrochloride
- 270/100
vivitrol
Naltrexone
- 3New
narcan
Naloxone Hydrochloride
- 4New
opvee
Nalmefene Hydrochloride
- 5New
relistor
Methylnaltrexone Bromide
- 6New
rezenopy
Naloxone Hydrochloride
- 7New
symproic
Naldemedine Tosylate
- 8New
zimhi
Naloxone Hydrochloride
- 9New
zurnai (autoinjector)
Nalmefene Hydrochloride
Frequently asked questions
What is the Opioid Antagonist drug class?
Opioid Antagonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 9 Opioid Antagonist products, each independently rated.
Are all Opioid Antagonist drugs the same?
No. Opioid Antagonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
What conditions do Opioid Antagonist drugs treat?
Per NIH RxClass drug-classification data, Opioid Antagonist drugs are used for conditions including opioid-related disorders, respiration disorders, shock, septic, alcoholism, drug overdose, constipation.
Which Opioid Antagonist drug is best-rated?
By our independent rating, naloxone currently ranks highest among Opioid Antagonist drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Opioid Antagonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Opioid Antagonists - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.