Best Opioid Antagonist for Constipation — ranked (2026) · pharmaranks
Best Opioid Antagonist for constipation
2 Opioid Antagonist drugs indicated for constipation, ranked by our independent rating. The current highest-rated is relistor. Compare them with all treatments for constipation or the full Opioid Antagonist class. Not medical advice — always consult a professional.
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Top opioid antagonist for constipation:1. Relistor · 2. Symproic
Best-rated Opioid Antagonist for constipation, ranked by pharmaranks score
What is the best opioid antagonist for constipation?
By our independent rating, relistor currently ranks highest among Opioid Antagonist drugs used for constipation. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Which opioid antagonist drugs treat constipation?
pharmaranks lists 2 Opioid Antagonist products indicated for constipation, per FDA drug-label data — each independently rated and ranked above.
How are these ranked?
By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.
symproic
PrescriptionFDA-sourced
New
SYMPROIC (naldemedine), an opioid antagonist, contains naldemedine tosylate as the active ingredient.