esclim
Esclim (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Estradiol · by Women First Hlthcare
Available as a generic: Estradiol
Key facts
- Active ingredient
- Estradiol
- Drug class
- Estrogen
- Form
- System
- Strength
- Estradiol 0.025MG/24HR · Estradiol 0.0375MG/24HR · Estradiol 0.05MG/24HR · Estradiol 0.075MG/24HR · Estradiol 0.1MG/24HR
- Type
- Prescription (Rx)
- Brand or generic
- Brand-name
- May treat
- breast neoplasms, hypogonadism, premature menopause
- Manufacturer
- Women First Hlthcare
- What the pharmacy pays
- ~$6.42 per gm — not your price
- FDA application
- NDA020847
- Availability
- Discontinued (per FDA)
Drug class
How this class works, per Estrogen - StatPearls - NCBI Bookshelf.
May treat (source: NIH RxClass)
- breast neoplasms
- hypogonadism
- premature menopause
- menorrhagia
- prostatic neoplasms
- primary ovarian insufficiency
See how Esclim ranks — best-rated estrogen for:
Dosage forms
System
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- What does Esclim treat?
- Esclim (Estradiol) may be used to treat breast neoplasms, hypogonadism, premature menopause, menorrhagia, prostatic neoplasms, primary ovarian insufficiency, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
- How does Esclim work?
- Esclim is a estrogen. Estrogen is a sex hormone that enters cells and binds estrogen receptors; the hormone-receptor complex then moves into the nucleus and switches target genes on or off. Through this it thickens the uterine lining, helps protect bone, supports breast and vaginal tissue, and shapes cholesterol levels.
- How much does Esclim cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $6.42 per gm, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Esclim?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Esclim. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Esclim?
- Esclim is marketed by Women First Hlthcare. You can see Women First Hlthcare's full profile, rating, and other products on pharmaranks.
- Is Esclim a brand-name or generic drug?
- Esclim is a brand-name product with the active ingredient Estradiol. Lower-cost generic equivalents containing Estradiol are available — ask your pharmacist.
- Is Esclim available over the counter?
- No. Esclim is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
- What forms does Esclim come in?
- Esclim is currently marketed as system, per the FDA's National Drug Code Directory.
- What class of drug is Esclim?
- Esclim is classified as estrogen, per the FDA's Established Pharmacologic Class.
- Is Esclim FDA-registered?
- Esclim is on record with the U.S. FDA under application number NDA020847. You can verify this on its official FDA label.
Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
What people report to the FDA about ESTRADIOL
The FDA Adverse Event Reporting System (FAERS) collects reports from patients and clinicians. It holds 81,226 reports naming ESTRADIOL — the active ingredient in Esclim, and the FDA flagged 51% of those reports as serious. The effects reported most often — leaving out reports about overdose, misuse or the condition being treated, which dominate the raw list for common medicines:
- product adhesion issue8,308 reports
- fatigue6,370 reports
- headache5,420 reports
- nausea5,319 reports
- dyspnoea4,641 reports
- rash4,525 reports
- pruritus4,446 reports
- arthralgia4,427 reports
Read these as a signal, not a rate. A report does not mean ESTRADIOL caused the effect — anyone can file one, and many describe people taking several medicines for several conditions. Crucially there is no denominator: FAERS does not record how many people took the drug, so these counts cannot be turned into “X% of patients” — a bigger number often just means a more widely used or more talked-about drug. Duplicates exist, and publicity drives reporting. For what is actually established, read the FDA label.
Source: openFDA drug/event (FAERS), retrieved September 25, 2026.
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