Best Estrogen for menopause, premature
Top-rated pick: Elestrin — pharmaranks score 70/100, the highest of the 12 Estrogen drugs used for menopause, premature, ranked by our independent FDA recall-safety score. Compare them with all treatments for menopause, premature or the full Estrogen class. Not medical advice — always consult a professional.
Quick answer: Of the 12 estrogen drugs we rate for menopause, premature, all are available as lower-cost generics, and most are topical. Our ranking reflects each drug’s FDA recall-safety record — not clinical effectiveness for menopause, premature; the right choice depends on your situation, so confirm it with your prescriber.
How estrogen work
Estrogen is a sex hormone that enters cells and binds estrogen receptors; the hormone-receptor complex then moves into the nucleus and switches target genes on or off. Through this it thickens the uterine lining, helps protect bone, supports breast and vaginal tissue, and shapes cholesterol levels.
Top estrogen for menopause, premature: 1. Elestrin · 2. Evamist · 3. Imvexxy
| # | Drug | Rating | Type | Form | Generic? | Pharmacy pays | |
|---|---|---|---|---|---|---|---|
| 1 | 70/100 | Prescription | Topical | Generic | $7 | View → | |
| 2 | 70/100 | Prescription | Spray/Inhaler | Generic | $7 | View → | |
| 3 | 70/100 | Prescription | Insert | Generic | $7 | View → | |
| 4 | 70/100 | Prescription | Insert | Generic | $7 | View → | |
| 5 | 68/100 | Prescription | Topical | Generic | $7 | View → | |
| 6 | 68/100 | Prescription | Patch | Generic | $7 | View → | |
| 7 | 64/100 | Prescription | System | Generic | $7 | View → | |
| 8 | 60/100 | Prescription | Film | Generic | $7 | View → | |
| 9 | Not yet rated | Prescription | Patch | Generic | $7 | View → | |
| 10 | Not yet rated | Prescription | Topical | Generic | $7 | View → |
Full ranking · 12 drugs
elestrin
Boxed warningPrescriptionFDA-sourced
Elestrin (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 forms
evamist
Boxed warningPrescriptionFDA-sourced
Evamist (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsimvexxy
PrescriptionFDA-sourced
Imvexxy (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsvagifem
Boxed warningPrescriptionFDA-sourced
Vagifem (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsestradiol
Boxed warningPrescriptionFDA-sourced
Estradiol is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 forms
vivelle-dot
Boxed warningPrescriptionFDA-sourced
Vivelle-Dot (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 forms
estring
PrescriptionFDA-sourced
Estring (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 forms
minivelle
Boxed warningPrescriptionFDA-sourced
Minivelle (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsclimara
Boxed warningPrescriptionFDA-sourced
Climara (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsestrogel
Boxed warningPrescriptionFDA-sourced
Estrogel (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsfemring
Boxed warningPrescriptionFDA-sourced
Femring (Estradiol Acetate) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsmenostar
Boxed warningPrescriptionFDA-sourced
Menostar (Estradiol) is an estrogen used to treat Breast Neoplasms, Hypogonadism, Premature Menopause, Menorrhagia.
Pharmacy pays
From ~$0.07· 8 formsFrequently asked
- What is the best estrogen for menopause, premature?
- By our independent recall-safety rating — not an efficacy measure — elestrin ranks highest among Estrogen drugs used for menopause, premature. Always consult a professional.
- Which estrogen drugs treat menopause, premature?
- pharmaranks lists 12 Estrogen products used for menopause, premature, per NIH RxClass drug-classification data — each independently rated and ranked above.
- How are these ranked?
- By our independent score, currently based on FDA regulatory recall-safety data (the methodology blends additional sources as they come online). See the How we rate page.